Granger causality analysis reveals the changes of thalamocortical functionality after cardiac arrest induced hypoxic-ischemic injury

Cheng Chen, Anil Maybhate, Nitish V. Thakor

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Hypoxic-ischemia (HI) following cardiac arrest (CA) induces a global injury to the brain that can lead to coma. Resuscitation may eventually lead to arousal from coma. During early arousal, how the functional connectivity between various important brain regions evolves may ultimately affect the outcome. In order to understand the changes in thalamocortical functionality through the injury and recovery periods, we recorded local field potentials (LFPs) from the ventroposterior lateral (VPL) nucleus of the thalamus and the forelimb somatosensory cortex (S1-FL) in a rat model of asphyxial CA. Granger causality was used to analyze the causal relationships between the thalamocortical LFPs. Preliminary results indicate that during early arousal, the thalamocortical dynamics is significantly unilateral with the thalamic centers driving the cortical regions and the driving strength decreased significantly upon CA and improved after resuscitation during arousal.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages63-64
Number of pages2
DOIs
StatePublished - Jun 29 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Publication series

Name2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
CountryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

ASJC Scopus subject areas

  • Bioengineering

Fingerprint Dive into the research topics of 'Granger causality analysis reveals the changes of thalamocortical functionality after cardiac arrest induced hypoxic-ischemic injury'. Together they form a unique fingerprint.

  • Cite this

    Chen, C., Maybhate, A., & Thakor, N. V. (2012). Granger causality analysis reveals the changes of thalamocortical functionality after cardiac arrest induced hypoxic-ischemic injury. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 63-64). [6206963] (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6206963