Graft versus host-like illness in a child with phenobarbital hypersensitivity

A. P. Knutsen, M. Shah, K. B. Schwarz, C. C. Tsai

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


A child in whom a phenobarbital hypersensitivity drug reaction developed which consisted of fever, a pruritic desquamating erythrodermic rash, alopecia, icterus, protein-losing enteropathy, myositis, and nephritis, is described. Laboratory studies demonstrated eosinophilia, elevated serum IgE, and elevated T suppressor/cytotoxic cells in the peripheral blood. Findings from biopsy specimens of skin and jejunum suggested a cell-mediated pathogenesis, and lymphoproliferative studies of the patient's mononuclear cells revealed a positive response to phenobarbital. The clinical findings and laboratory studies suggested an autoimmune cell-mediated hypersensitivity reaction triggered by phenobarbital.

Original languageEnglish (US)
Pages (from-to)581-584
Number of pages4
Issue number4
StatePublished - Jan 1 1986
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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