Gradual dose taper following chronic buprenorphine

A. B. Becker, E. C. Strain, G. E. Bigelow, M. L. Stitzer, R. E. Johnson

Research output: Contribution to journalArticle

Abstract

This paper describes the time course of withdrawal and relapse in opioid-dependent volunteers (n = 8) who completed a gradual outpatient buprenorphine dose taper (28 days). Compliance with treatment was very high, as evidenced by clinic attendance (96-100%). Urinalysis showed that 6 of the 8 volunteers had relapsed to opiates by the end of the dose taper, even though reports of withdrawal were generally low. Relapse may have been triggered by a desire to re-experience the drug's positive subjective effects, craving, or low motivation to remain drug-free. A longer taper combined with an expanded range of treatments may improve prognosis.

Original languageEnglish (US)
Pages (from-to)111-121
Number of pages11
JournalAmerican Journal on Addictions
Volume10
Issue number2
DOIs
StatePublished - Jan 1 2001

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Clinical Psychology
  • Psychiatry and Mental health

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