Gradual dose taper following chronic buprenorphine

A. B. Becker, Eric C Strain, George Bigelow, Maxine L Stitzer, R. E. Johnson

Research output: Contribution to journalArticle

Abstract

This paper describes the time course of withdrawal and relapse in opioid-dependent volunteers (n = 8) who completed a gradual outpatient buprenorphine dose taper (28 days). Compliance with treatment was very high, as evidenced by clinic attendance (96-100%). Urinalysis showed that 6 of the 8 volunteers had relapsed to opiates by the end of the dose taper, even though reports of withdrawal were generally low. Relapse may have been triggered by a desire to re-experience the drug's positive subjective effects, craving, or low motivation to remain drug-free. A longer taper combined with an expanded range of treatments may improve prognosis.

Original languageEnglish (US)
Pages (from-to)111-121
Number of pages11
JournalAmerican Journal on Addictions
Volume10
Issue number2
DOIs
StatePublished - 2001

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Buprenorphine
Opiate Alkaloids
Volunteers
Recurrence
Urinalysis
Pharmaceutical Preparations
Opioid Analgesics
Motivation
Outpatients
Therapeutics
Craving

ASJC Scopus subject areas

  • Medicine (miscellaneous)

Cite this

Gradual dose taper following chronic buprenorphine. / Becker, A. B.; Strain, Eric C; Bigelow, George; Stitzer, Maxine L; Johnson, R. E.

In: American Journal on Addictions, Vol. 10, No. 2, 2001, p. 111-121.

Research output: Contribution to journalArticle

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