Graded levels of Ptf1a differentially regulate endocrine and exocrine fates in the developing pancreas

P. Duc Si Dong, Elayne Provost, Steven D. Leach, Didier Y.R. Stainier

Research output: Contribution to journalArticlepeer-review

Abstract

The mechanisms regulating pancreatic endocrine versus exocrine fate are not well defined. By analyzing the effects of Ptf1a partial loss of function, we uncovered novel roles for this transcription factor in determining pancreatic fates. In a newly identified hypomorphic ptf1a mutant, pancreatic cells that would normally express ptf1a and become exocrine cells, express the endocrine marker Isl1, indicating a cell fate switch. Surprisingly, a milder reduction of Ptf1a leads to an even greater increase of ectopic endocrine cells, suggesting that Ptf1a also plays a role in promoting endocrine development. We propose that low levels of Ptf1a promote endocrine fate, whereas high levels repress endocrine fate and promote exocrine fate.

Original languageEnglish (US)
Pages (from-to)1445-1450
Number of pages6
JournalGenes and Development
Volume22
Issue number11
DOIs
StatePublished - Jun 1 2008

Keywords

  • Diabetes
  • Endocrine
  • Exocrine
  • Pancreas
  • Ptf1a

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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