Abstract
Triazole antifungal drugs may rarely cause serious allergic reactions including angioedema. No standardized tests are available to predict cross-reactivity within the azole class and little guiding information exists on whether to change therapy within the class or to another class after a serious allergic reaction. Herein we report the first successful use, to our knowledge, of graded isavuconazole introduction for treatment of aspergillosis in a liver transplant recipient with severe voriconazole allergy.
Original language | English (US) |
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Article number | e12772 |
Journal | Transplant Infectious Disease |
Volume | 19 |
Issue number | 6 |
DOIs | |
State | Published - Dec 2017 |
Keywords
- angioedema
- azole allergy
- azole cross-reactivity
- isavuconazole challenge
- voriconazole allergy
ASJC Scopus subject areas
- Infectious Diseases
- Transplantation