Graded effects of pulsed electric fields on contractility of single heart cells

Michele R. Mulligan, Rory J. O'Neill, Paul C. Zei, Leslie Tung

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effects of high-intensity electric fields on excitability and contractility of the heart at the cellular level are pertinent to defibrillation and electrical ablation. Stimulation of single cardiac cells with a rectangular pulsed electric field elicits twitch contraction. Variation of the stimulus intensity and duration shows a distinct strength-duration curve for the threshold of excitation, T1. T1 is mediated by the cell orientation with respect to the electric field (parallel or perpendicular). Above the threshold level is a second threshold level, T2, for cellular contracture. T2 has a shape similar to that of T1, and may be a consequence of formation of pores in the cell membrane (electroporation).

Original languageEnglish (US)
Title of host publicationIEEE/Engineering in Medicine and Biology Society Annual Conference
PublisherPubl by IEEE
Pages902-903
Number of pages2
Volume10
Editionpt2
StatePublished - Nov 1988
EventProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA
Duration: Nov 4 1988Nov 7 1988

Other

OtherProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityNew Orleans, LA, USA
Period11/4/8811/7/88

Fingerprint

Electric fields
Cell membranes
Ablation

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Mulligan, M. R., O'Neill, R. J., Zei, P. C., & Tung, L. (1988). Graded effects of pulsed electric fields on contractility of single heart cells. In IEEE/Engineering in Medicine and Biology Society Annual Conference (pt2 ed., Vol. 10, pp. 902-903). Publ by IEEE.

Graded effects of pulsed electric fields on contractility of single heart cells. / Mulligan, Michele R.; O'Neill, Rory J.; Zei, Paul C.; Tung, Leslie.

IEEE/Engineering in Medicine and Biology Society Annual Conference. Vol. 10 pt2. ed. Publ by IEEE, 1988. p. 902-903.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Mulligan, MR, O'Neill, RJ, Zei, PC & Tung, L 1988, Graded effects of pulsed electric fields on contractility of single heart cells. in IEEE/Engineering in Medicine and Biology Society Annual Conference. pt2 edn, vol. 10, Publ by IEEE, pp. 902-903, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, New Orleans, LA, USA, 11/4/88.
Mulligan MR, O'Neill RJ, Zei PC, Tung L. Graded effects of pulsed electric fields on contractility of single heart cells. In IEEE/Engineering in Medicine and Biology Society Annual Conference. pt2 ed. Vol. 10. Publ by IEEE. 1988. p. 902-903
Mulligan, Michele R. ; O'Neill, Rory J. ; Zei, Paul C. ; Tung, Leslie. / Graded effects of pulsed electric fields on contractility of single heart cells. IEEE/Engineering in Medicine and Biology Society Annual Conference. Vol. 10 pt2. ed. Publ by IEEE, 1988. pp. 902-903
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