Graded effects of pulsed electric fields on contractility of single heart cells

Michele R. Mulligan, Rory J. O'Neill, Paul C. Zei, Leslie Tung

Research output: Contribution to conferencePaperpeer-review

Abstract

The effects of high-intensity electric fields on excitability and contractility of the heart at the cellular level are pertinent to defibrillation and electrical ablation. Stimulation of single cardiac cells with a rectangular pulsed electric field elicits twitch contraction. Variation of the stimulus intensity and duration shows a distinct strength-duration curve for the threshold of excitation, T1. T1 is mediated by the cell orientation with respect to the electric field (parallel or perpendicular). Above the threshold level is a second threshold level, T2, for cellular contracture. T2 has a shape similar to that of T1, and may be a consequence of formation of pores in the cell membrane (electroporation).

Original languageEnglish (US)
Pages902-903
Number of pages2
StatePublished - Nov 1 1988
EventProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA
Duration: Nov 4 1988Nov 7 1988

Other

OtherProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityNew Orleans, LA, USA
Period11/4/8811/7/88

ASJC Scopus subject areas

  • Engineering(all)

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