gp120 neurotoxicity in primary cortical cultures

Research output: Contribution to journalArticlepeer-review

Abstract

The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in a nitric oxide dependent manner in primary cortical cultures at low picomolar concentrations. gp120 neurotoxicity also requires calcium and glutamate and is blocked by glutamate receptor antagonists. In addition, superoxide anions play a role in gp120 neurotoxicity since superoxide dismutase also attenuates neurotoxicity.

Original languageEnglish (US)
Pages (from-to)167-173
Number of pages7
JournalAdvances in Neuroimmunology
Volume4
Issue number3
DOIs
StatePublished - 1994

ASJC Scopus subject areas

  • Neuroscience(all)
  • Immunology

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