Gp120 activates children's brain endothelial cells via CD4

M. F. Stins, Y. Shen, S. H. Huang, F. Gilles, V. K. Kalra, K. S. Kim

Research output: Contribution to journalArticle

Abstract

Encephalopathy represents a common and serious manifestation of HIV-1 infection in children, but its pathogenesis is unclear. We demonstrated that gp120 activated human brain microvascular endothelial cells (HBMEC) derived from children in up-regulating ICAM-1 and VCAM-1 expression, IL-6 secretion and increased monocyte transmigration across monolayers. Another novel observation was our demonstration of CD4 in isolated HBMEC and on microvessels of children's brain cryosections. Gp120-induced monocyte migration was inhibited by anti-gp120 and anti-CD4 antibodies. This is the first demonstration that gp120 activates HBMEC via CD4, which may contribute to the development of HIV-1 encephalopathy in children.

Original languageEnglish (US)
Pages (from-to)125-134
Number of pages10
JournalJournal of neurovirology
Volume7
Issue number2
DOIs
StatePublished - Aug 8 2001
Externally publishedYes

Keywords

  • CD4
  • HIV-1
  • Human cerebral microvessel endothelium
  • ICAM-1
  • Transendothelial migration of monocytes
  • VCAM-1
  • gp120

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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