Abstract
Encephalopathy represents a common and serious manifestation of HIV-1 infection in children, but its pathogenesis is unclear. We demonstrated that gp120 activated human brain microvascular endothelial cells (HBMEC) derived from children in up-regulating ICAM-1 and VCAM-1 expression, IL-6 secretion and increased monocyte transmigration across monolayers. Another novel observation was our demonstration of CD4 in isolated HBMEC and on microvessels of children's brain cryosections. Gp120-induced monocyte migration was inhibited by anti-gp120 and anti-CD4 antibodies. This is the first demonstration that gp120 activates HBMEC via CD4, which may contribute to the development of HIV-1 encephalopathy in children.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 125-134 |
| Number of pages | 10 |
| Journal | Journal of neurovirology |
| Volume | 7 |
| Issue number | 2 |
| DOIs | |
| State | Published - Aug 8 2001 |
| Externally published | Yes |
Keywords
- CD4
- HIV-1
- Human cerebral microvessel endothelium
- ICAM-1
- Transendothelial migration of monocytes
- VCAM-1
- gp120
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Virology
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Stins, M. F., Shen, Y., Huang, S. H., Gilles, F., Kalra, V. K., & Kim, K. S. (2001). Gp120 activates children's brain endothelial cells via CD4. Journal of neurovirology, 7(2), 125-134. https://doi.org/10.1080/13550280152058780