Gout in older adults

The atherosclerosis risk in communities study

Bridget Teevan Burke, Anna Köttgen, Andrew Law, Morgan Grams, Alan Baer, Josef Coresh, Mara Ann McAdams Demarco

Research output: Contribution to journalArticle

Abstract

Background: It is unclear whether traditional and genetic risk factors in middle age predict the onset of gout in older age. Methods: We studied the incidence of gout in older adults using the Atherosclerosis Risk in Communities study, a prospective U.S. population- based cohort of middle- Aged adults enrolled between 1987 and 1989 with ongoing follow-up. A genetic urate score was formed from common urate- Associated single nucleotide polymorphisms for eight genes. The adjusted hazard ratio and 95% confidence interval of incident gout by traditional and genetic risk factors in middle age were estimated using a Cox proportional hazards model. Results: The cumulative incidence from middle age to age 65 was 8.6% in men and 2.5% in women; by age 75 the cumulative incidence was 11.8% and 5.0%. In middle age, increased adiposity, beer intake, protein intake, smoking status, hypertension, diuretic use, and kidney function (but not sex) were associated with an increased gout risk in older age. In addition, a 100 μmol/L increase in genetic urate score was associated with a 3.29-fold (95% confidence interval: 1.63-6.63) increased gout risk in older age. Conclusions: These findings suggest that traditional and genetic risk factors in middle age may be useful for identifying those at risk of gout in older age.

Original languageEnglish (US)
Pages (from-to)536-542
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume71
Issue number4
DOIs
StatePublished - Apr 1 2016

Fingerprint

Gout
Atherosclerosis
Uric Acid
Incidence
Confidence Intervals
Adiposity
Age of Onset
Proportional Hazards Models
Diuretics
Single Nucleotide Polymorphism
Smoking
Prospective Studies
Hypertension
Kidney
Population
Genes
Proteins

Keywords

  • Gout
  • Urate genetics

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Cite this

Gout in older adults : The atherosclerosis risk in communities study. / Burke, Bridget Teevan; Köttgen, Anna; Law, Andrew; Grams, Morgan; Baer, Alan; Coresh, Josef; McAdams Demarco, Mara Ann.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 71, No. 4, 01.04.2016, p. 536-542.

Research output: Contribution to journalArticle

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