TY - JOUR
T1 - Gout in older adults
T2 - The atherosclerosis risk in communities study
AU - Burke, Bridget Teevan
AU - Köttgen, Anna
AU - Law, Andrew
AU - Grams, Morgan
AU - Baer, Alan N.
AU - Coresh, Josef
AU - McAdams-DeMarco, Mara A.
N1 - Publisher Copyright:
©The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Background: It is unclear whether traditional and genetic risk factors in middle age predict the onset of gout in older age. Methods: We studied the incidence of gout in older adults using the Atherosclerosis Risk in Communities study, a prospective U.S. population- based cohort of middle- Aged adults enrolled between 1987 and 1989 with ongoing follow-up. A genetic urate score was formed from common urate- Associated single nucleotide polymorphisms for eight genes. The adjusted hazard ratio and 95% confidence interval of incident gout by traditional and genetic risk factors in middle age were estimated using a Cox proportional hazards model. Results: The cumulative incidence from middle age to age 65 was 8.6% in men and 2.5% in women; by age 75 the cumulative incidence was 11.8% and 5.0%. In middle age, increased adiposity, beer intake, protein intake, smoking status, hypertension, diuretic use, and kidney function (but not sex) were associated with an increased gout risk in older age. In addition, a 100 μmol/L increase in genetic urate score was associated with a 3.29-fold (95% confidence interval: 1.63-6.63) increased gout risk in older age. Conclusions: These findings suggest that traditional and genetic risk factors in middle age may be useful for identifying those at risk of gout in older age.
AB - Background: It is unclear whether traditional and genetic risk factors in middle age predict the onset of gout in older age. Methods: We studied the incidence of gout in older adults using the Atherosclerosis Risk in Communities study, a prospective U.S. population- based cohort of middle- Aged adults enrolled between 1987 and 1989 with ongoing follow-up. A genetic urate score was formed from common urate- Associated single nucleotide polymorphisms for eight genes. The adjusted hazard ratio and 95% confidence interval of incident gout by traditional and genetic risk factors in middle age were estimated using a Cox proportional hazards model. Results: The cumulative incidence from middle age to age 65 was 8.6% in men and 2.5% in women; by age 75 the cumulative incidence was 11.8% and 5.0%. In middle age, increased adiposity, beer intake, protein intake, smoking status, hypertension, diuretic use, and kidney function (but not sex) were associated with an increased gout risk in older age. In addition, a 100 μmol/L increase in genetic urate score was associated with a 3.29-fold (95% confidence interval: 1.63-6.63) increased gout risk in older age. Conclusions: These findings suggest that traditional and genetic risk factors in middle age may be useful for identifying those at risk of gout in older age.
KW - Gout
KW - Urate genetics
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U2 - 10.1093/gerona/glv120
DO - 10.1093/gerona/glv120
M3 - Article
C2 - 26714568
AN - SCOPUS:84964843238
SN - 1079-5006
VL - 71
SP - 536
EP - 542
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 4
ER -