GOSR2 Lys67Arg is associated with hypertension in whites

Tamra E. Meyer, Dov Shiffman, Alanna C. Morrison, Charles M. Rowland, Judy Z. Louie, Lance A. Bare, David A. Ross, Andre R. Arellano, Daniel I. Chasman, Paul M. Ridker, James S. Pankow, Josef Coresh, Mary J. Malloy, John P. Kane, Stephen G. Ellis, James J. Devlin, Eric Boerwinkle

Research output: Contribution to journalArticle

Abstract

Background: Hypertension is a risk factor for coronary heart disease (CHD), but the causes of hypertension remain largely unknown. Genetic variation is thought to contribute to the etiology of hypertension. We tested a single-nucleotide polymorphism (SNP) (Lys67Arg, rs197922) in the Golgi SNAP Receptor Complex Member 2 (GOSR2) gene for association with hypertension and blood pressure (BP). We chose this SNP because it was nominally associated with CHD in earlier studies. Further, GOSR2 is located in a linkage region for hypertension and BP in human and animal studies. Methods: We used logistic and linear regression to test associations of the GOSR2 SNP with hypertension and BP among 3,528 blacks and 9,861 whites from the Atherosclerosis Risk in Communities (ARIC) study. Race-specific regression models of hypertension were adjusted for age and gender. Regression models of BP were further adjusted for antihypertensive medication use. Results: The GOSR2 Lys67 allele was associated with hypertension in whites (odds ratio (OR) = 1.09, P = 0.01) but not blacks (OR = 0.96, P = 0.47). The Lys67 allele was associated with increased systolic BP (SBP) in both races (0.87 mm Hg, P <0.001 among whites and 1.05 mm Hg, P = 0.05 among blacks). A similar association in whites was observed for the GOSR2 SNP and SBP in the Women's Genome Health Study (WGHS) (OR = 1.03, P = 0.04). The OR remained unchanged after adjustment for antihypertensive medication use (OR = 1.03, P = 0.11), though it was no longer statistically significant. Conclusions: We found evidence that a SNP in GOSR2 is modestly associated with hypertension in whites from the ARIC study and the WGHS.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalAmerican Journal of Hypertension
Volume22
Issue number2
DOIs
StatePublished - Feb 16 2009

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SNARE Proteins
Hypertension
Single Nucleotide Polymorphism
Blood Pressure
Odds Ratio
Women's Health
Antihypertensive Agents
Coronary Disease
Atherosclerosis
Alleles
Genome
Linear Models
Logistic Models

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Meyer, T. E., Shiffman, D., Morrison, A. C., Rowland, C. M., Louie, J. Z., Bare, L. A., ... Boerwinkle, E. (2009). GOSR2 Lys67Arg is associated with hypertension in whites. American Journal of Hypertension, 22(2), 163-168. https://doi.org/10.1038/ajh.2008.336

GOSR2 Lys67Arg is associated with hypertension in whites. / Meyer, Tamra E.; Shiffman, Dov; Morrison, Alanna C.; Rowland, Charles M.; Louie, Judy Z.; Bare, Lance A.; Ross, David A.; Arellano, Andre R.; Chasman, Daniel I.; Ridker, Paul M.; Pankow, James S.; Coresh, Josef; Malloy, Mary J.; Kane, John P.; Ellis, Stephen G.; Devlin, James J.; Boerwinkle, Eric.

In: American Journal of Hypertension, Vol. 22, No. 2, 16.02.2009, p. 163-168.

Research output: Contribution to journalArticle

Meyer, TE, Shiffman, D, Morrison, AC, Rowland, CM, Louie, JZ, Bare, LA, Ross, DA, Arellano, AR, Chasman, DI, Ridker, PM, Pankow, JS, Coresh, J, Malloy, MJ, Kane, JP, Ellis, SG, Devlin, JJ & Boerwinkle, E 2009, 'GOSR2 Lys67Arg is associated with hypertension in whites', American Journal of Hypertension, vol. 22, no. 2, pp. 163-168. https://doi.org/10.1038/ajh.2008.336
Meyer TE, Shiffman D, Morrison AC, Rowland CM, Louie JZ, Bare LA et al. GOSR2 Lys67Arg is associated with hypertension in whites. American Journal of Hypertension. 2009 Feb 16;22(2):163-168. https://doi.org/10.1038/ajh.2008.336
Meyer, Tamra E. ; Shiffman, Dov ; Morrison, Alanna C. ; Rowland, Charles M. ; Louie, Judy Z. ; Bare, Lance A. ; Ross, David A. ; Arellano, Andre R. ; Chasman, Daniel I. ; Ridker, Paul M. ; Pankow, James S. ; Coresh, Josef ; Malloy, Mary J. ; Kane, John P. ; Ellis, Stephen G. ; Devlin, James J. ; Boerwinkle, Eric. / GOSR2 Lys67Arg is associated with hypertension in whites. In: American Journal of Hypertension. 2009 ; Vol. 22, No. 2. pp. 163-168.
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abstract = "Background: Hypertension is a risk factor for coronary heart disease (CHD), but the causes of hypertension remain largely unknown. Genetic variation is thought to contribute to the etiology of hypertension. We tested a single-nucleotide polymorphism (SNP) (Lys67Arg, rs197922) in the Golgi SNAP Receptor Complex Member 2 (GOSR2) gene for association with hypertension and blood pressure (BP). We chose this SNP because it was nominally associated with CHD in earlier studies. Further, GOSR2 is located in a linkage region for hypertension and BP in human and animal studies. Methods: We used logistic and linear regression to test associations of the GOSR2 SNP with hypertension and BP among 3,528 blacks and 9,861 whites from the Atherosclerosis Risk in Communities (ARIC) study. Race-specific regression models of hypertension were adjusted for age and gender. Regression models of BP were further adjusted for antihypertensive medication use. Results: The GOSR2 Lys67 allele was associated with hypertension in whites (odds ratio (OR) = 1.09, P = 0.01) but not blacks (OR = 0.96, P = 0.47). The Lys67 allele was associated with increased systolic BP (SBP) in both races (0.87 mm Hg, P <0.001 among whites and 1.05 mm Hg, P = 0.05 among blacks). A similar association in whites was observed for the GOSR2 SNP and SBP in the Women's Genome Health Study (WGHS) (OR = 1.03, P = 0.04). The OR remained unchanged after adjustment for antihypertensive medication use (OR = 1.03, P = 0.11), though it was no longer statistically significant. Conclusions: We found evidence that a SNP in GOSR2 is modestly associated with hypertension in whites from the ARIC study and the WGHS.",
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T1 - GOSR2 Lys67Arg is associated with hypertension in whites

AU - Meyer, Tamra E.

AU - Shiffman, Dov

AU - Morrison, Alanna C.

AU - Rowland, Charles M.

AU - Louie, Judy Z.

AU - Bare, Lance A.

AU - Ross, David A.

AU - Arellano, Andre R.

AU - Chasman, Daniel I.

AU - Ridker, Paul M.

AU - Pankow, James S.

AU - Coresh, Josef

AU - Malloy, Mary J.

AU - Kane, John P.

AU - Ellis, Stephen G.

AU - Devlin, James J.

AU - Boerwinkle, Eric

PY - 2009/2/16

Y1 - 2009/2/16

N2 - Background: Hypertension is a risk factor for coronary heart disease (CHD), but the causes of hypertension remain largely unknown. Genetic variation is thought to contribute to the etiology of hypertension. We tested a single-nucleotide polymorphism (SNP) (Lys67Arg, rs197922) in the Golgi SNAP Receptor Complex Member 2 (GOSR2) gene for association with hypertension and blood pressure (BP). We chose this SNP because it was nominally associated with CHD in earlier studies. Further, GOSR2 is located in a linkage region for hypertension and BP in human and animal studies. Methods: We used logistic and linear regression to test associations of the GOSR2 SNP with hypertension and BP among 3,528 blacks and 9,861 whites from the Atherosclerosis Risk in Communities (ARIC) study. Race-specific regression models of hypertension were adjusted for age and gender. Regression models of BP were further adjusted for antihypertensive medication use. Results: The GOSR2 Lys67 allele was associated with hypertension in whites (odds ratio (OR) = 1.09, P = 0.01) but not blacks (OR = 0.96, P = 0.47). The Lys67 allele was associated with increased systolic BP (SBP) in both races (0.87 mm Hg, P <0.001 among whites and 1.05 mm Hg, P = 0.05 among blacks). A similar association in whites was observed for the GOSR2 SNP and SBP in the Women's Genome Health Study (WGHS) (OR = 1.03, P = 0.04). The OR remained unchanged after adjustment for antihypertensive medication use (OR = 1.03, P = 0.11), though it was no longer statistically significant. Conclusions: We found evidence that a SNP in GOSR2 is modestly associated with hypertension in whites from the ARIC study and the WGHS.

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