Good cell culture practices &in vitro toxicology

Chantra Eskes, Ann Charlotte Boström, Gerhard Bowe, Sandra Coecke, Thomas Hartung, Giel Hendriks, David Pamies, Alain Piton, Costanza Rovida

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Good Cell Culture Practices (GCCP) is of high relevance to in vitro toxicology. The European Society of Toxicology In Vitro (ESTIV), the Center for Alternatives for Animal Testing (CAAT) and the In Vitro Toxicology Industrial Platform (IVTIP) joined forces to address by means of an ESTIV 2016 pre-congress session the different aspects and applications of GCCP. The covered aspects comprised the current status of the OECD guidance document on Good In Vitro Method Practices, the importance of quality assurance for new technological advances in in vitro toxicology including stem cells, and the optimized implementation of Good Manufacturing Practices and Good Laboratory Practices for regulatory testing purposes. General discussions raised the duality related to the difficulties in implementing GCCP in an academic innovative research framework on one hand, and on the other hand, the need for such GCCP principles in order to ensure reproducibility and robustness of in vitro test methods for toxicity testing. Indeed, if good cell culture principles are critical to take into consideration for all uses of in vitro test methods for toxicity testing, the level of application of such principles may depend on the stage of development of the test method as well as on the applications of the test methods, i.e., academic innovative research vs. regulatory standardized test method.

Original languageEnglish (US)
JournalToxicology in Vitro
StateAccepted/In press - Mar 7 2017


  • Complex in vitro systems
  • Good cell culture practices
  • Good in vitro method practices
  • Good laboratory practices
  • Good manufacturing practices
  • Stem-cells

ASJC Scopus subject areas

  • Toxicology


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