TY - JOUR
T1 - Good cell culture practices &in vitro toxicology
AU - Eskes, Chantra
AU - Boström, Ann Charlotte
AU - Bowe, Gerhard
AU - Coecke, Sandra
AU - Hartung, Thomas
AU - Hendriks, Giel
AU - Pamies, David
AU - Piton, Alain
AU - Rovida, Costanza
PY - 2017/3/7
Y1 - 2017/3/7
N2 - Good Cell Culture Practices (GCCP) is of high relevance to in vitro toxicology. The European Society of Toxicology In Vitro (ESTIV), the Center for Alternatives for Animal Testing (CAAT) and the In Vitro Toxicology Industrial Platform (IVTIP) joined forces to address by means of an ESTIV 2016 pre-congress session the different aspects and applications of GCCP. The covered aspects comprised the current status of the OECD guidance document on Good In Vitro Method Practices, the importance of quality assurance for new technological advances in in vitro toxicology including stem cells, and the optimized implementation of Good Manufacturing Practices and Good Laboratory Practices for regulatory testing purposes. General discussions raised the duality related to the difficulties in implementing GCCP in an academic innovative research framework on one hand, and on the other hand, the need for such GCCP principles in order to ensure reproducibility and robustness of in vitro test methods for toxicity testing. Indeed, if good cell culture principles are critical to take into consideration for all uses of in vitro test methods for toxicity testing, the level of application of such principles may depend on the stage of development of the test method as well as on the applications of the test methods, i.e., academic innovative research vs. regulatory standardized test method.
AB - Good Cell Culture Practices (GCCP) is of high relevance to in vitro toxicology. The European Society of Toxicology In Vitro (ESTIV), the Center for Alternatives for Animal Testing (CAAT) and the In Vitro Toxicology Industrial Platform (IVTIP) joined forces to address by means of an ESTIV 2016 pre-congress session the different aspects and applications of GCCP. The covered aspects comprised the current status of the OECD guidance document on Good In Vitro Method Practices, the importance of quality assurance for new technological advances in in vitro toxicology including stem cells, and the optimized implementation of Good Manufacturing Practices and Good Laboratory Practices for regulatory testing purposes. General discussions raised the duality related to the difficulties in implementing GCCP in an academic innovative research framework on one hand, and on the other hand, the need for such GCCP principles in order to ensure reproducibility and robustness of in vitro test methods for toxicity testing. Indeed, if good cell culture principles are critical to take into consideration for all uses of in vitro test methods for toxicity testing, the level of application of such principles may depend on the stage of development of the test method as well as on the applications of the test methods, i.e., academic innovative research vs. regulatory standardized test method.
KW - Complex in vitro systems
KW - Good cell culture practices
KW - Good in vitro method practices
KW - Good laboratory practices
KW - Good manufacturing practices
KW - Stem-cells
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U2 - 10.1016/j.tiv.2017.04.022
DO - 10.1016/j.tiv.2017.04.022
M3 - Article
C2 - 28450071
AN - SCOPUS:85019569593
JO - Toxicology in Vitro
JF - Toxicology in Vitro
SN - 0887-2333
ER -