Good Cell Culture Practice (GCCP)--eine Initiative zur Standardisierung und Qualitätssicherung von in vitro Arbeiten. Die Etablierung einer ECVAM Task Force on GCCP.

Translated title of the contribution: Good cell culture practice (GCCP)--an initiative for standardization and quality control of in vitro studies. The establishment of an ECVAM Task Force on GCCP

Thomas Hartung, G. Gstraunthaler, S. Coecke, D. Lewis, O. Blanck, M. Balls

Research output: Contribution to journalArticle

Abstract

Cultured human and animal cells are increasingly used as the basis for simplified, direct test systems that have the potential to be more controllable and more reproducible than in vivo test systems. However, if a biological test system is simplified to fundamental levels then it is paramount that the essential components of such a reduced systems are closely defined and reproducible. Thus, minimal requirements for quality standards in cell and tissue culture have to be defined. It is the aim of this GCCP initiative to establish principles for standardisation, rationalisation, and international harmonisation of cell and tissue culture laboratory practices. Therefore, in analogy to Good Laboratory Practice (GLP), a Good Cell Culture Practice (GCCP) was initiated at the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, Bologna, 29. August-2. September 1999. This "Bologna Statement on Good Cell Culture Practice" was presented, discussed, and refined in a Workshop, and a final version was approved at the closing ceremony of the Congress by the scientific audience. Based on the Bologna Statement, an ECVAM Task Force on GCCP was initiated, that is chaired by Thomas Hartung and Sandra Ceocke, in which experts in the field should elaborate minimal requirements for quality standards in cell culture. It is the intention of the GCCP Guidelines to encourage consensus among all concerned with the use of in vitro systems, in order to establish and maintain best laboratory practices, to promote effective quality control systems, to facilitate education and training, to support journal editors, and to help any authorities who need to interpret and apply conclusions based on in vitro data.

Original languageGerman
Pages (from-to)75-78
Number of pages4
JournalAltex
Volume18
Issue number1
StatePublished - 2001
Externally publishedYes

Fingerprint

Advisory Committees
Quality Control
Cell Culture Techniques
Practice Guidelines
Animal Use Alternatives
Education
Training Support
Biological Science Disciplines
In Vitro Techniques
Consensus

ASJC Scopus subject areas

  • Medical Laboratory Technology
  • Medicine (miscellaneous)

Cite this

Good Cell Culture Practice (GCCP)--eine Initiative zur Standardisierung und Qualitätssicherung von in vitro Arbeiten. Die Etablierung einer ECVAM Task Force on GCCP. / Hartung, Thomas; Gstraunthaler, G.; Coecke, S.; Lewis, D.; Blanck, O.; Balls, M.

In: Altex, Vol. 18, No. 1, 2001, p. 75-78.

Research output: Contribution to journalArticle

@article{a2f3e2dc162744cabbbb96b23beff4dc,
title = "Good Cell Culture Practice (GCCP)--eine Initiative zur Standardisierung und Qualit{\"a}tssicherung von in vitro Arbeiten. Die Etablierung einer ECVAM Task Force on GCCP.",
abstract = "Cultured human and animal cells are increasingly used as the basis for simplified, direct test systems that have the potential to be more controllable and more reproducible than in vivo test systems. However, if a biological test system is simplified to fundamental levels then it is paramount that the essential components of such a reduced systems are closely defined and reproducible. Thus, minimal requirements for quality standards in cell and tissue culture have to be defined. It is the aim of this GCCP initiative to establish principles for standardisation, rationalisation, and international harmonisation of cell and tissue culture laboratory practices. Therefore, in analogy to Good Laboratory Practice (GLP), a Good Cell Culture Practice (GCCP) was initiated at the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, Bologna, 29. August-2. September 1999. This {"}Bologna Statement on Good Cell Culture Practice{"} was presented, discussed, and refined in a Workshop, and a final version was approved at the closing ceremony of the Congress by the scientific audience. Based on the Bologna Statement, an ECVAM Task Force on GCCP was initiated, that is chaired by Thomas Hartung and Sandra Ceocke, in which experts in the field should elaborate minimal requirements for quality standards in cell culture. It is the intention of the GCCP Guidelines to encourage consensus among all concerned with the use of in vitro systems, in order to establish and maintain best laboratory practices, to promote effective quality control systems, to facilitate education and training, to support journal editors, and to help any authorities who need to interpret and apply conclusions based on in vitro data.",
author = "Thomas Hartung and G. Gstraunthaler and S. Coecke and D. Lewis and O. Blanck and M. Balls",
year = "2001",
language = "German",
volume = "18",
pages = "75--78",
journal = "ALTEX : Alternativen zu Tierexperimenten",
issn = "1868-596X",
publisher = "Elsevier GmbH",
number = "1",

}

TY - JOUR

T1 - Good Cell Culture Practice (GCCP)--eine Initiative zur Standardisierung und Qualitätssicherung von in vitro Arbeiten. Die Etablierung einer ECVAM Task Force on GCCP.

AU - Hartung, Thomas

AU - Gstraunthaler, G.

AU - Coecke, S.

AU - Lewis, D.

AU - Blanck, O.

AU - Balls, M.

PY - 2001

Y1 - 2001

N2 - Cultured human and animal cells are increasingly used as the basis for simplified, direct test systems that have the potential to be more controllable and more reproducible than in vivo test systems. However, if a biological test system is simplified to fundamental levels then it is paramount that the essential components of such a reduced systems are closely defined and reproducible. Thus, minimal requirements for quality standards in cell and tissue culture have to be defined. It is the aim of this GCCP initiative to establish principles for standardisation, rationalisation, and international harmonisation of cell and tissue culture laboratory practices. Therefore, in analogy to Good Laboratory Practice (GLP), a Good Cell Culture Practice (GCCP) was initiated at the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, Bologna, 29. August-2. September 1999. This "Bologna Statement on Good Cell Culture Practice" was presented, discussed, and refined in a Workshop, and a final version was approved at the closing ceremony of the Congress by the scientific audience. Based on the Bologna Statement, an ECVAM Task Force on GCCP was initiated, that is chaired by Thomas Hartung and Sandra Ceocke, in which experts in the field should elaborate minimal requirements for quality standards in cell culture. It is the intention of the GCCP Guidelines to encourage consensus among all concerned with the use of in vitro systems, in order to establish and maintain best laboratory practices, to promote effective quality control systems, to facilitate education and training, to support journal editors, and to help any authorities who need to interpret and apply conclusions based on in vitro data.

AB - Cultured human and animal cells are increasingly used as the basis for simplified, direct test systems that have the potential to be more controllable and more reproducible than in vivo test systems. However, if a biological test system is simplified to fundamental levels then it is paramount that the essential components of such a reduced systems are closely defined and reproducible. Thus, minimal requirements for quality standards in cell and tissue culture have to be defined. It is the aim of this GCCP initiative to establish principles for standardisation, rationalisation, and international harmonisation of cell and tissue culture laboratory practices. Therefore, in analogy to Good Laboratory Practice (GLP), a Good Cell Culture Practice (GCCP) was initiated at the 3rd World Congress on Alternatives and Animal Use in the Life Sciences, Bologna, 29. August-2. September 1999. This "Bologna Statement on Good Cell Culture Practice" was presented, discussed, and refined in a Workshop, and a final version was approved at the closing ceremony of the Congress by the scientific audience. Based on the Bologna Statement, an ECVAM Task Force on GCCP was initiated, that is chaired by Thomas Hartung and Sandra Ceocke, in which experts in the field should elaborate minimal requirements for quality standards in cell culture. It is the intention of the GCCP Guidelines to encourage consensus among all concerned with the use of in vitro systems, in order to establish and maintain best laboratory practices, to promote effective quality control systems, to facilitate education and training, to support journal editors, and to help any authorities who need to interpret and apply conclusions based on in vitro data.

UR - http://www.scopus.com/inward/record.url?scp=0035236521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035236521&partnerID=8YFLogxK

M3 - Article

C2 - 11248855

AN - SCOPUS:0035236521

VL - 18

SP - 75

EP - 78

JO - ALTEX : Alternativen zu Tierexperimenten

JF - ALTEX : Alternativen zu Tierexperimenten

SN - 1868-596X

IS - 1

ER -