Gonadotropin stimulation protocols in the norfolk IVF program-1988

Georgeanna S. Jones, Suheil J. Muasher, Liu Hung-Ching

Research output: Contribution to journalArticlepeer-review


A standard FSH/hMG stimulation protocol applied to all patients does not yield optimum results. In the Norfolk program it has been found that the determination of FSH/LH ratio on day 3 of the menstrual cycle provides a predictive signal of the likelihood of a good or bad response to a standard protocol. If the FSH is high in relation to LH, the patient will likely be a low responder and/or approaching the menopause. A regime of high-dose pure FSH seems to improve the number of eggs in this group and therefore the pregnancy rate. On the other hand, if the FSH/LH ratio is very low, that is, the patient has a high LH, the patient is generally a high responder and produces many eggs, but in some instances the quality of eggs is suspect, and the pregnancy rate is low in a particular subset of high responders. The use of GnRHa and/or minimal stimulation with FSH or hMG seems to improve the pregnancy rate.

Original languageEnglish (US)
Pages (from-to)823-825
Number of pages3
JournalJournal of Steroid Biochemistry
Issue number4 PART 2
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology


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