TY - JOUR
T1 - Gonadotropin stimulation protocols in the norfolk IVF program-1988
AU - Jones, Georgeanna S.
AU - Muasher, Suheil J.
AU - Hung-Ching, Liu
PY - 1989/10
Y1 - 1989/10
N2 - A standard FSH/hMG stimulation protocol applied to all patients does not yield optimum results. In the Norfolk program it has been found that the determination of FSH/LH ratio on day 3 of the menstrual cycle provides a predictive signal of the likelihood of a good or bad response to a standard protocol. If the FSH is high in relation to LH, the patient will likely be a low responder and/or approaching the menopause. A regime of high-dose pure FSH seems to improve the number of eggs in this group and therefore the pregnancy rate. On the other hand, if the FSH/LH ratio is very low, that is, the patient has a high LH, the patient is generally a high responder and produces many eggs, but in some instances the quality of eggs is suspect, and the pregnancy rate is low in a particular subset of high responders. The use of GnRHa and/or minimal stimulation with FSH or hMG seems to improve the pregnancy rate.
AB - A standard FSH/hMG stimulation protocol applied to all patients does not yield optimum results. In the Norfolk program it has been found that the determination of FSH/LH ratio on day 3 of the menstrual cycle provides a predictive signal of the likelihood of a good or bad response to a standard protocol. If the FSH is high in relation to LH, the patient will likely be a low responder and/or approaching the menopause. A regime of high-dose pure FSH seems to improve the number of eggs in this group and therefore the pregnancy rate. On the other hand, if the FSH/LH ratio is very low, that is, the patient has a high LH, the patient is generally a high responder and produces many eggs, but in some instances the quality of eggs is suspect, and the pregnancy rate is low in a particular subset of high responders. The use of GnRHa and/or minimal stimulation with FSH or hMG seems to improve the pregnancy rate.
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U2 - 10.1016/0022-4731(89)90500-1
DO - 10.1016/0022-4731(89)90500-1
M3 - Article
C2 - 2513456
AN - SCOPUS:0024789732
SN - 0022-4731
VL - 33
SP - 823
EP - 825
JO - Journal of Steroid Biochemistry
JF - Journal of Steroid Biochemistry
IS - 4 PART 2
ER -