Gonadotropin output and response to lrh administration in congenital virilizing adrenal hyperplasia

Anne Colston Wentz, Silviacristina Garcia, Georgeannajones Klingensmith, Claude J. Migeon, Georgeannaseeger Jones

Research output: Contribution to journalArticle

Abstract

Three premenarchial, 2 primary amenorrheic, and 5 post-menarchial patients with congenital virilizing adrenal hyperplasia (CAH) were examined, utilizing frequent blood sampling techniques and the administration of synthetic luteinizing hormone-releasing hormone (LHRH) to determine whether a normal pattern of gonadotropin output occurs in CAH. Pulsatile gonadotropin output was not observed in premenarchial patients, but was seen in all who had had spontaneous menses. Bone age did not correlate with baseline or episodic gonadotropin output, or with response to LRH, but did reflect the past or present therapeutic control. The normal developmental progression of gonadotropin output was only documented in those patients who had been maintained at doses of suppressive glucocorticoids appropriate for body surface.

Original languageEnglish (US)
Pages (from-to)239-246
Number of pages8
JournalJournal of Clinical Endocrinology and Metabolism
Volume42
Issue number2
DOIs
StatePublished - Feb 1976

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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