Gonadotrophin ovulation induction and enhancement outcomes: Analysis of more than 1400 cycles

Abbaa Sarhan, Hind Beydoun, Howard W. Jones, Silvina Bocca, Sergio Oehninger, Laurel Stadtmauer

Research output: Contribution to journalArticle

Abstract

Ovulation induction (OI) or ovulation enhancement (OE) with gonadotrophins can be a reasonable treatment option for patients with a variety of infertility diagnoses. It must be used with extensive monitoring and management given the risk of multiple pregnancy, especially high-order multiples. This retrospective study evaluated per cycle outcomes of a large cohort of 1452 gonadotrophin OI/OE cycles at an academic infertility centre, and the efficacy of specific guidelines in limiting multiple pregnancy. The lowest possible gonadotrophin doses were used and cycle cancellation was recommended if more than three dominant follicles were present, and/or if serum oestradiol was above 1500 pg/ml. Overall, pregnancy rate (PR) was 12% and live birth rate was 7.7%, with an increasing trend in younger patients (P = 0.0002 and 1500 pg/ml.

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalReproductive BioMedicine Online
Volume23
Issue number2
DOIs
StatePublished - Aug 2011
Externally publishedYes

Fingerprint

Ovulation Induction
Gonadotropins
Multiple Pregnancy
Ovulation
Infertility
Birth Rate
Risk Management
Live Birth
Pregnancy Rate
Estradiol
Retrospective Studies
Guidelines
Serum
Therapeutics

Keywords

  • birthweight
  • multiple birth
  • multiple pregnancy
  • ovulation enhancement
  • ovulation induction
  • vanishing twin

ASJC Scopus subject areas

  • Reproductive Medicine
  • Developmental Biology

Cite this

Gonadotrophin ovulation induction and enhancement outcomes : Analysis of more than 1400 cycles. / Sarhan, Abbaa; Beydoun, Hind; Jones, Howard W.; Bocca, Silvina; Oehninger, Sergio; Stadtmauer, Laurel.

In: Reproductive BioMedicine Online, Vol. 23, No. 2, 08.2011, p. 220-226.

Research output: Contribution to journalArticle

Sarhan, A, Beydoun, H, Jones, HW, Bocca, S, Oehninger, S & Stadtmauer, L 2011, 'Gonadotrophin ovulation induction and enhancement outcomes: Analysis of more than 1400 cycles', Reproductive BioMedicine Online, vol. 23, no. 2, pp. 220-226. https://doi.org/10.1016/j.rbmo.2011.05.002
Sarhan, Abbaa ; Beydoun, Hind ; Jones, Howard W. ; Bocca, Silvina ; Oehninger, Sergio ; Stadtmauer, Laurel. / Gonadotrophin ovulation induction and enhancement outcomes : Analysis of more than 1400 cycles. In: Reproductive BioMedicine Online. 2011 ; Vol. 23, No. 2. pp. 220-226.
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