Gonadal steroid receptor mRNA in catecholaminergic nuclei of the canary brainstem

Donna L. Maney; Daniel J. Bernard; Gregory F. Ball

doi:10.1016/S0304-3940(01)02157-7

Gonadal steroid receptor mRNA in catecholaminergic nuclei of the canary brainstem

Donna L. Maney, Daniel J. Bernard, Gregory F. Ball

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Steroid actions in the song system may be modulated by ascending inputs from catecholaminergic (CA) brain nuclei; however, whether these nuclei contain steroid receptors is unknown. Here, we compared the distribution of androgen receptor (AR) and estrogen receptor-alpha (ER-α) mRNA with that of tyrosine hydroxylase immunoreactivity (TH-IR) in the brainstems of male canaries. Areas containing AR and ER-α mRNA overlapped with areas containing TH-IR cell bodies in the locus ceruleus and the area ventralis of Tsai. The substantia nigra and the midbrain central gray contained both TH-IR and AR mRNA. The presence of AR and ER-α within CA cell groups suggests that sex steroid hormones may modulate song production at the site of CA synthesis.

Original language	English (US)
Pages (from-to)	189-192
Number of pages	4
Journal	Neuroscience Letters
Volume	311
Issue number	3
DOIs	https://doi.org/10.1016/S0304-3940(01)02157-7
State	Published - Oct 5 2001
Externally published	Yes

Keywords

Androgen receptor
Area ventralis
Central gray
Estrogen receptor
Locus ceruleus
Song
Tyrosine hydroxylase

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0304-3940(01)02157-7

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@article{19edb2e69c4041079851efb3debfe239,

title = "Gonadal steroid receptor mRNA in catecholaminergic nuclei of the canary brainstem",

abstract = "Steroid actions in the song system may be modulated by ascending inputs from catecholaminergic (CA) brain nuclei; however, whether these nuclei contain steroid receptors is unknown. Here, we compared the distribution of androgen receptor (AR) and estrogen receptor-alpha (ER-α) mRNA with that of tyrosine hydroxylase immunoreactivity (TH-IR) in the brainstems of male canaries. Areas containing AR and ER-α mRNA overlapped with areas containing TH-IR cell bodies in the locus ceruleus and the area ventralis of Tsai. The substantia nigra and the midbrain central gray contained both TH-IR and AR mRNA. The presence of AR and ER-α within CA cell groups suggests that sex steroid hormones may modulate song production at the site of CA synthesis.",

keywords = "Androgen receptor, Area ventralis, Central gray, Estrogen receptor, Locus ceruleus, Song, Tyrosine hydroxylase",

author = "Maney, {Donna L.} and Bernard, {Daniel J.} and Ball, {Gregory F.}",

note = "Funding Information: We thank Brian Spar for administrative assistance and Jacques Balthazart and an anonymous reviewer for thoughtful comments on the manuscript. This research was supported by grants from the National Science Foundation (DBN 9804129) and the National Institutes of Health (RO1 NS 35467).",

year = "2001",

month = oct,

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doi = "10.1016/S0304-3940(01)02157-7",

language = "English (US)",

volume = "311",

pages = "189--192",

journal = "Neuroscience Letters",

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T1 - Gonadal steroid receptor mRNA in catecholaminergic nuclei of the canary brainstem

AU - Maney, Donna L.

AU - Bernard, Daniel J.

AU - Ball, Gregory F.

N1 - Funding Information: We thank Brian Spar for administrative assistance and Jacques Balthazart and an anonymous reviewer for thoughtful comments on the manuscript. This research was supported by grants from the National Science Foundation (DBN 9804129) and the National Institutes of Health (RO1 NS 35467).

PY - 2001/10/5

Y1 - 2001/10/5

N2 - Steroid actions in the song system may be modulated by ascending inputs from catecholaminergic (CA) brain nuclei; however, whether these nuclei contain steroid receptors is unknown. Here, we compared the distribution of androgen receptor (AR) and estrogen receptor-alpha (ER-α) mRNA with that of tyrosine hydroxylase immunoreactivity (TH-IR) in the brainstems of male canaries. Areas containing AR and ER-α mRNA overlapped with areas containing TH-IR cell bodies in the locus ceruleus and the area ventralis of Tsai. The substantia nigra and the midbrain central gray contained both TH-IR and AR mRNA. The presence of AR and ER-α within CA cell groups suggests that sex steroid hormones may modulate song production at the site of CA synthesis.

AB - Steroid actions in the song system may be modulated by ascending inputs from catecholaminergic (CA) brain nuclei; however, whether these nuclei contain steroid receptors is unknown. Here, we compared the distribution of androgen receptor (AR) and estrogen receptor-alpha (ER-α) mRNA with that of tyrosine hydroxylase immunoreactivity (TH-IR) in the brainstems of male canaries. Areas containing AR and ER-α mRNA overlapped with areas containing TH-IR cell bodies in the locus ceruleus and the area ventralis of Tsai. The substantia nigra and the midbrain central gray contained both TH-IR and AR mRNA. The presence of AR and ER-α within CA cell groups suggests that sex steroid hormones may modulate song production at the site of CA synthesis.

KW - Androgen receptor

KW - Area ventralis

KW - Central gray

KW - Estrogen receptor

KW - Locus ceruleus

KW - Song

KW - Tyrosine hydroxylase

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U2 - 10.1016/S0304-3940(01)02157-7

DO - 10.1016/S0304-3940(01)02157-7

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EP - 192

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 3

ER -

Gonadal steroid receptor mRNA in catecholaminergic nuclei of the canary brainstem

Abstract

Keywords

ASJC Scopus subject areas

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