Gonadal morphology in cloacal exstrophy: Implications in gender assignment

R. I. Mathews, E. Perlman, D. W. Marsh, John Phillip Gearhart

Research output: Contribution to journalArticle

Abstract

Objective: To compare the histology of gonads excised from males with cloacal exstrophy (the most severe variant of the exstrophy-epispadias complex) undergoing early gonadectomy and gender reassignment (to obviate difficulties in reconstructing male external genitalia) with those published previously. Patients and methods: Testicular tissue was obtained from males with cloacal exstrophy undergoing gender reassignment shortly after birth. Slides were stained for histological evaluation and reviewed by one author. The histology was compared with known normal features for newborn testicular tissue. The mean age at the time of gender reassignment was 6 months. Results: There were no significant abnormalities in the architecture of the rete testis, epididymis or vas of the study specimens. There were more germ cells in some patients with cloacal exstrophy, but this finding was not specific and is of unknown clinical significance. Conclusions: Despite the severity of the malformations in cloacal exstrophy, testicular histology is preserved. In highly selected genotypic males who have adequate phallic structures, congruent gender assignment is appropriate and early orchidopexy is recommended.

Original languageEnglish (US)
Pages (from-to)99-100
Number of pages2
JournalBJU International
Volume84
Issue number1
DOIs
StatePublished - 1999

Fingerprint

Histology
Epispadias
Rete Testis
Male Genitalia
Orchiopexy
Epididymis
Gonads
Germ Cells
Parturition
Newborn Infant

Keywords

  • Cloacal exstrophy
  • Gender assignment
  • Histology
  • Testis

ASJC Scopus subject areas

  • Urology

Cite this

Gonadal morphology in cloacal exstrophy : Implications in gender assignment. / Mathews, R. I.; Perlman, E.; Marsh, D. W.; Gearhart, John Phillip.

In: BJU International, Vol. 84, No. 1, 1999, p. 99-100.

Research output: Contribution to journalArticle

Mathews, R. I. ; Perlman, E. ; Marsh, D. W. ; Gearhart, John Phillip. / Gonadal morphology in cloacal exstrophy : Implications in gender assignment. In: BJU International. 1999 ; Vol. 84, No. 1. pp. 99-100.
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