Golgi structure in stress sensing and apoptosis

Stuart W. Hicks, Carolyn E. Machamer

Research output: Contribution to journalReview articlepeer-review

Abstract

The Golgi complex in mammalian cells is composed of polarized stacks of flattened cisternal membranes. Stacks are connected by tubules forming a reticular network of membranes closely associated with the microtubule- organizing center. While the Golgi structure is important for the efficient processing of secretory cargo, the organization of the mammalian Golgi complex may indicate potential functions in addition to the processing and sorting of cargo. Similar to the endoplasmic reticulum stress response pathway, the Golgi complex may initiate signaling pathways to alleviate stress, and if irreparable, trigger apoptosis. Here, we review recent experimental evidence suggesting that the elaborate structure of the Golgi complex in mammalian cells may have evolved to sense and transduce stress signals.

Original languageEnglish (US)
Pages (from-to)406-414
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1744
Issue number3 SPEC. ISS.
DOIs
StatePublished - Jul 10 2005

Keywords

  • Apoptosis
  • Caspase cleavage
  • Golgi complex
  • Golgi structure
  • Golgin
  • Signaling

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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