Golgi protein ACBD3 mediates neurotoxicity associated with huntington's disease

Research output: Contribution to journalArticle

Abstract

Huntington@s disease (HD) is an autosomal-dominant neurodegenerative disease caused by the expansion of polyglutamine repeats in the gene for huntingtin (. Htt). In HD, the corpus striatum selectively degenerates despite the uniform expression of mutant huntingtin (mHtt) throughout the brain and body. Striatal selectivity reflects the binding of the striatal-selective protein Rhes to mHtt to augment cytotoxicity, but molecular mechanisms underlying the toxicity have been elusive. Here, we report that the Golgi protein acyl-CoA binding domain containing 3 (ACBD3) mediates mHtt cytotoxicity via a Rhes/mHtt/ACBD3 complex. ACBD3 levels are markedly elevated in the striatum of HD patients, in a striatal cell line harboring polyglutamine repeats, and in the brains of HD mice. Moreover, ACBD3 deletion abolishes HD neurotoxicity, which is increased by ACBD3 overexpression. Enhanced levels of ACBD3 elicited by endoplasmic reticulum, mitochondrial, and Golgi stresses may account for HD-associated augmentation of ACBD3 and neurodegeneration

Original languageEnglish (US)
Pages (from-to)890-897
Number of pages8
JournalCell Reports
Volume4
Issue number5
DOIs
StatePublished - May 12 2013

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Diazepam Binding Inhibitor
Acyl Coenzyme A
Huntington Disease
Corpus Striatum
Cytotoxicity
Brain
Neurodegenerative diseases
Endoplasmic Reticulum
Neurodegenerative Diseases
Toxicity
Genes
Cells
Cell Line

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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Golgi protein ACBD3 mediates neurotoxicity associated with huntington's disease. / Sbodio, Juan; Paul, Bindu; Machamer, Carolyn E; Snyder, Solomon H.

In: Cell Reports, Vol. 4, No. 5, 12.05.2013, p. 890-897.

Research output: Contribution to journalArticle

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