Golgi disassembly in apoptosis: Cause or effect?

Research output: Contribution to journalArticle

Abstract

The Golgi complex undergoes a dramatic disassembly process during apoptosis. Some Golgi proteins implicated in Golgi structure and vesicle transport are cleaved during apoptosis, and expression of noncleavable mutants of these proteins delays Golgi disassembly after pro-apoptotic stimuli. Cleavage of Golgi structural proteins and subsequent disassembly of the organelle could simply be the result of the apoptotic process. However, recent studies raise the intriguing possibility that cleavage of Golgi proteins during apoptosis might be required for more than disassembly of the organelle.

Original languageEnglish (US)
Pages (from-to)279-281
Number of pages3
JournalTrends in Cell Biology
Volume13
Issue number6
DOIs
StatePublished - Jun 1 2003

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Apoptosis
Organelles
Transport Vesicles
Proteins
Golgi Apparatus
Mutant Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Golgi disassembly in apoptosis : Cause or effect? / Machamer, Carolyn E.

In: Trends in Cell Biology, Vol. 13, No. 6, 01.06.2003, p. 279-281.

Research output: Contribution to journalArticle

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