Golestan cohort study of oesophageal cancer: Feasibility and first results

A. Pourshams, M. Saadatian-Elahi, M. Nouraie, A. F. Malekshah, N. Rakhshani, R. Salahi, A. Yoonessi, S. Semnani, F. Islami, M. Sotoudeh, S. Fahimi, A. R. Sadjadi, D. Nasrollahzadeh, K. Aghcheli, F. Kamangar, C. C. Abnet, F. Saidi, V. Sewram, Paul Timothy Strickland, S. M. DawseyP. Brennan, P. Boffetta, R. Malekzadeh

Research output: Contribution to journalArticle

Abstract

To investigate the incidence of oesophageal cancer (EC) in the Golestan province of North-East Iran, we invited 1349 rural and urban inhabitants of Golestan province aged 35-80 to undergo extensive lifestyle interviews and to provide biological samples. The interview was repeated on a subset of 130 participants to assess reliability of questionnaire and medical information. Temperature at which tea was consumed was measured on two occasions by 110 subjects. Samples of rice, wheat and sorghum were tested for fumonisin contamination. An active follow-up was carried out after 6 and 12 months. A total of 1057 subjects (610 women and 447 men) participated in this feasibility study (78.4% participation rate). Cigarette smoking, opium and alcohol use were reported by 163 (13.8%), 93 (8.8%) and 39 (3.7%) subjects, respectively. Tobacco smoking was correlated with urinary cotinine (κ = 0.74). Most questionnaire data had κ > 0.7 in repeat measurements; tea temperature measurement was reliable (κ = 0.71). No fumonisins were detected in the samples analysed. During the follow-up six subjects were lost (0.6%), two subjects developed EC (one dead, one alive); in all, 13 subjects died (with cause of death known for 11, 84.6%). Conducting a cohort study in Golestan is feasible with reliable information obtained for suspected risk factors; participants can be followed up for EC incidence and mortality.

Original languageEnglish (US)
Pages (from-to)176-181
Number of pages6
JournalBritish Journal of Cancer
Volume92
Issue number1
DOIs
StatePublished - Jan 17 2005

Fingerprint

Fumonisins
Tea
Esophageal Neoplasms
Cohort Studies
Smoking
Interviews
Opium
Cotinine
Temperature
Sorghum
Incidence
Feasibility Studies
Iran
Triticum
Life Style
Cause of Death
Alcohols
Mortality
Surveys and Questionnaires
Oryza

Keywords

  • Cohort
  • Golestan
  • Iran
  • Oesophageal cancer
  • Turkmen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Pourshams, A., Saadatian-Elahi, M., Nouraie, M., Malekshah, A. F., Rakhshani, N., Salahi, R., ... Malekzadeh, R. (2005). Golestan cohort study of oesophageal cancer: Feasibility and first results. British Journal of Cancer, 92(1), 176-181. https://doi.org/10.1038/sj.bjc.6602249

Golestan cohort study of oesophageal cancer : Feasibility and first results. / Pourshams, A.; Saadatian-Elahi, M.; Nouraie, M.; Malekshah, A. F.; Rakhshani, N.; Salahi, R.; Yoonessi, A.; Semnani, S.; Islami, F.; Sotoudeh, M.; Fahimi, S.; Sadjadi, A. R.; Nasrollahzadeh, D.; Aghcheli, K.; Kamangar, F.; Abnet, C. C.; Saidi, F.; Sewram, V.; Strickland, Paul Timothy; Dawsey, S. M.; Brennan, P.; Boffetta, P.; Malekzadeh, R.

In: British Journal of Cancer, Vol. 92, No. 1, 17.01.2005, p. 176-181.

Research output: Contribution to journalArticle

Pourshams, A, Saadatian-Elahi, M, Nouraie, M, Malekshah, AF, Rakhshani, N, Salahi, R, Yoonessi, A, Semnani, S, Islami, F, Sotoudeh, M, Fahimi, S, Sadjadi, AR, Nasrollahzadeh, D, Aghcheli, K, Kamangar, F, Abnet, CC, Saidi, F, Sewram, V, Strickland, PT, Dawsey, SM, Brennan, P, Boffetta, P & Malekzadeh, R 2005, 'Golestan cohort study of oesophageal cancer: Feasibility and first results', British Journal of Cancer, vol. 92, no. 1, pp. 176-181. https://doi.org/10.1038/sj.bjc.6602249
Pourshams A, Saadatian-Elahi M, Nouraie M, Malekshah AF, Rakhshani N, Salahi R et al. Golestan cohort study of oesophageal cancer: Feasibility and first results. British Journal of Cancer. 2005 Jan 17;92(1):176-181. https://doi.org/10.1038/sj.bjc.6602249
Pourshams, A. ; Saadatian-Elahi, M. ; Nouraie, M. ; Malekshah, A. F. ; Rakhshani, N. ; Salahi, R. ; Yoonessi, A. ; Semnani, S. ; Islami, F. ; Sotoudeh, M. ; Fahimi, S. ; Sadjadi, A. R. ; Nasrollahzadeh, D. ; Aghcheli, K. ; Kamangar, F. ; Abnet, C. C. ; Saidi, F. ; Sewram, V. ; Strickland, Paul Timothy ; Dawsey, S. M. ; Brennan, P. ; Boffetta, P. ; Malekzadeh, R. / Golestan cohort study of oesophageal cancer : Feasibility and first results. In: British Journal of Cancer. 2005 ; Vol. 92, No. 1. pp. 176-181.
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AU - Malekshah, A. F.

AU - Rakhshani, N.

AU - Salahi, R.

AU - Yoonessi, A.

AU - Semnani, S.

AU - Islami, F.

AU - Sotoudeh, M.

AU - Fahimi, S.

AU - Sadjadi, A. R.

AU - Nasrollahzadeh, D.

AU - Aghcheli, K.

AU - Kamangar, F.

AU - Abnet, C. C.

AU - Saidi, F.

AU - Sewram, V.

AU - Strickland, Paul Timothy

AU - Dawsey, S. M.

AU - Brennan, P.

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