Gold nanocages for cancer detection and treatment

Sara E. Skrabalak, Leslie Au, Xianmao Lu, Xingde Li, Younan Xia

Research output: Contribution to journalReview articlepeer-review

Abstract

Gold nanocages represent a novel class of biocompatible vectors with potential applications in drug delivery, tumor/tissue imaging and photothermal therapy. They are prepared through the galvanio-replacement reaction between Ag nanostructures and HAuCl4. By controlling the amount of HAuCl4 added, we can tune the surface-plasmon resonance peaks of the Au nanocages into the near-infrared, where the attenuation of light by blood and soft tissue is relatively low. Here, we highlight recent advances in the synthesis and utilization of Au nanocages for cancer detection and treatment. We have tailored the optical properties of Au nanocages for use as contrast agents in optical coherenoe tomography and astransducers for the selective photothermal ablation of cancer cells. Our results show improved optical coherence tomography image contrast when Au nanocages are added to tissue phantoms as well as the selective photothermal destruction of breast cancer cells in vitro when immunotargeted Au nanocages are used.

Original languageEnglish (US)
Pages (from-to)657-668
Number of pages12
JournalNanomedicine
Volume2
Issue number5
DOIs
StatePublished - Oct 2007
Externally publishedYes

Keywords

  • Contrast agents
  • Drug delivery
  • Metal nanoparticles
  • Nanocages
  • Photothermal therapy
  • SPR

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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