Gold nanocages: Bioconjugation and their potential use as optical imaging contrast agents

Jingyi Chen, Fusayo Saeki, Benjamin J. Wiley, Hu Cang, Michael J. Cobb, Zhi Yuan Li, Leslie Au, Hui Zhang, Michael B. Kimmey, Xingde Li, Younan Xia

Research output: Contribution to journalArticle

Abstract

Gold nanocages of <40 nm in dimension have been synthesized using the galvanic replacement reaction between Ag nanocubes and HAuCl 4 in an aqueous solution. By controlling the molar ratio between Ag and HAuCl 4, the gold nanocages could be tuned to display surface plasmon resonance peaks around 800 nm, a wavelength commonly used in optical coherence tomography (OCT) imaging. OCT measurements on phantom samples indicate that these gold nanocages have a moderate scattering cross-section of ∼8.10 × 10 -16 m 2 but a very large absorption cross-section of ∼7.26 × 10 -15 m 2, suggesting their potential use as a new class of contrast agents for optical imaging. When bioconjugated with antibodies, the gold nanocages have also been demonstrated for specific targeting of breast cancer cells.

Original languageEnglish (US)
Pages (from-to)473-477
Number of pages5
JournalNano Letters
Volume5
Issue number3
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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  • Cite this

    Chen, J., Saeki, F., Wiley, B. J., Cang, H., Cobb, M. J., Li, Z. Y., Au, L., Zhang, H., Kimmey, M. B., Li, X., & Xia, Y. (2005). Gold nanocages: Bioconjugation and their potential use as optical imaging contrast agents. Nano Letters, 5(3), 473-477. https://doi.org/10.1021/nl047950t