Gold nanocages as contrast agents for spectroscopic optical coherence tomography

Hu Cang, Tao Sun, Zhi Yuan Li, Jingyi Chen, Benjamin J. Wiley, Younan Xia, Xingde Li

Research output: Contribution to journalArticle

Abstract

We describe gold nanocages as a new class of potential contrast agent for spectroscopic optical coherence tomography (OCT). Monodispersed gold nanocages of an ∼35 nm edge length exhibit strong optical resonance, with the peak wavelength tunable in the near-infrared range. We characterized the optical properties of the nanocage by using OCT experiments along with numerical calculations, revealing an absorption cross section approximately 5 orders of magnitude larger than conventional dyes. Experiments with tissue phantoms demonstrated that the nanocages provide enhanced contrast for spectroscopic as well as conventional intensity-based OCT imaging.

Original languageEnglish (US)
Pages (from-to)3048-3050
Number of pages3
JournalOptics Letters
Volume30
Issue number22
DOIs
StatePublished - Nov 15 2005
Externally publishedYes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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