Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery

Sanyang Han, Animesh Samanta, Xiaoji Xie, Ling Huang, Juanjuan Peng, Sung Jin Park, Daniel Boon Loong Teh, Yongdoo Choi, Young Tae Chang, Angelo Homayoun All, Yanmei Yang, Bengang Xing, Xiaogang Liu

Research output: Contribution to journalArticle

Abstract

Although multifunctional upconversion imaging probes have recently attracted considerable interest in biomedical research, there are currently few methods for stabilizing these luminescent nanoprobes with oligonucleotides in biological systems. Herein, a method to robustly disperse upconversion nanoprobes in physiological buffers based on rational design and synthesis of nanoconjugates comprising hairpin-DNA-modified gold nanoparticles is presented. This approach imparts the upconversion nanoprobes with excellent biocompatibility and circumvents the problem of particle agglomeration. By combining single-band anti-Stokes near-infrared emission and the photothermal effect mediated by the coupling of gold to upconversion nanoparticles, a simple, versatile nanoparticulate system for simultaneous deep-tissue imaging and drug molecule release in vivo is demonstrated.

Original languageEnglish (US)
JournalAdvanced Materials
DOIs
StateAccepted/In press - 2017

Keywords

  • Deep tissue imaging
  • Drug delivery
  • Hairpin DNA
  • Surface functionalization
  • Upconversion nanoprobes

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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    Han, S., Samanta, A., Xie, X., Huang, L., Peng, J., Park, S. J., Teh, D. B. L., Choi, Y., Chang, Y. T., All, A. H., Yang, Y., Xing, B., & Liu, X. (Accepted/In press). Gold and Hairpin DNA Functionalization of Upconversion Nanocrystals for Imaging and In Vivo Drug Delivery. Advanced Materials. https://doi.org/10.1002/adma.201700244