Goblet cell response to vitamin a treatment for corneal xerophthalmia

Alfred Sommer, William R. Green

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

In 11 patients with active corneal xerophthalmia, conjunctival biopsies were obtained at various intervals after massive-dose systemic vitamin A therapy. Goblet cells began to repopulate the inferonasal quadrant of the conjunctivas after two weeks, and they reached normal concentrations after one month. Corneal healing proceeded much more rapidly than that, suggesting that a full complement of mucus-secreting conjunctival goblet cells is not essential for restoration and maintenance of normal corneal appearance.

Original languageEnglish (US)
Pages (from-to)213-215
Number of pages3
JournalAmerican journal of ophthalmology
Volume94
Issue number2
DOIs
StatePublished - Aug 1982

ASJC Scopus subject areas

  • Ophthalmology

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