Abstract
Whole tumor cells that secrete GM-CSF have been tested in clinical trials and have demonstrated early evidence of safety and clinical activity. The intradermal administration of these cells induces a massive infiltration of dendritic cells, which process and present tumor antigens to activate tumor-specific CD4+ and CD8+ T-cells. However, trial design flaws limit the phase III evaluation of this vaccine platform. Preclinical and clinical data suggest the development of GM-CSF-secreting tumor vaccines should be continued in combination with drugs that enhance vaccine activity by mitigating immune tolerance or augmenting costimulatory pathways of T-cell activation.
Original language | English (US) |
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Pages (from-to) | 1315-1324 |
Number of pages | 10 |
Journal | Current Opinion in Investigational Drugs |
Volume | 10 |
Issue number | 12 |
State | Published - Dec 1 2009 |
Keywords
- Cancer vaccine
- Clinical trial
- GM-CSF
- Immunotherapy
- Solid tumor
- Tumor cell vaccine
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery