GM-CSF-based cellular vaccines: A review of the clinical experience

Research output: Contribution to journalShort survey

Abstract

Immunotherapy is playing an increasing role in the treatment of many cancers. The recent advances in antibody therapy gives much optimism that both passive (antibody therapy) as well as active (vaccine therapy) immunotherapeutic interventions will acquire an increasing presence in oncology. Granulocyte macrophage-colony stimulation factor (GM-CSF)-based vaccines have now been tested in several diseases in a variety of formulations. The success and broad applicability of such an approach rests on the development of an ideal vaccine formulation administered in the appropriate clinical context. This review summarizes the results from the clinical trials performed to date and discusses the future directions of GM-CSF-based cellular vaccine strategies aimed at maximizing the therapeutic benefit.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalCytokine and Growth Factor Reviews
Volume13
Issue number2
DOIs
StatePublished - Mar 26 2002

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Keywords

  • Cancer
  • GM-CSF
  • Immunotherapy
  • Vaccines

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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