Glycosphingolipids in patients with the Rett syndrome

Subroto Chatterjee, Nupur Ghosh, Keow Mei Goh, Edgar Rohmann, Wolfgang Killian, Andreas Rett

Research output: Contribution to journalArticlepeer-review

Abstract

We have pursued two blind studies on the plasma glycosphingolipids in patients with the Rett syndrome (RS), other disorders and normal individuals from Baltimore, USA, Vienna, Austria, and Rostock, East Germany. We found the presence of an unusual glycosphingolipid in 70% of patients with RS. Approximately 10% of the plasma from patients with other developmental disorders also contained this glycosphingolipid. However, this glycosphingolipid was absent from the plasma of normal individuals and lipid storage disorders. Further work in this area will be necessary to associate the relevance of this finding to RS.

Original languageEnglish (US)
Pages (from-to)85-87
Number of pages3
JournalBrain and Development
Volume12
Issue number1
DOIs
StatePublished - 1990

Keywords

  • Rett syndrome
  • glycosphingolipid

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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