Glycosaminoglycans in follicular fluid from women undergoing in vitro fertilization and their relationship to cumulus expansion, fertilization, and development

M. E. Bellin, R. L. Ax, N. Laufer, B. C. Tarlatzis, A. H. DeCherney, D. Feldberg, F. P. Haseltine

Research output: Contribution to journalArticlepeer-review

Abstract

The glycosaminoglycans (GAGs) chondroitin sulfate (CS) and heparan sulfate (HS) were assayed in fluid from 178 individual follicles obtained from women after human menopausal gonadotropin ovulation induction for subsequent in vitro fertilization. CS and HS concentrations ranged from 0 to 3.9 and 0 to 18.6 mg/ml, respectively. The percentage of oocytes fertilized was significantly higher when CS concentrations ranged from 0.3 to 0.8 mg/ml (P < 0.03). As HS levels increased, maturation scores by visual assessment of the egg-corona-cumulus cell complexes increased (P < 0.05), but the percentage of oocytes fertilized was not affected. Cleavage rates of developing embryos were not related to the concentrations of GAGs.

Original languageEnglish (US)
Pages (from-to)244-248
Number of pages5
JournalFertility and sterility
Volume45
Issue number2
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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