Abstract
7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-d-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding to the PCP receptor, and that this effect is reversed by addittion of glycine. Since [3H]MK-801 binding is a measure of channel activation, our results are consistents with the hypothesis that 7-Cl KYNA exerts its NMDA receptor antagonism by acting at the glycine site, and that activation of the glycine site is required for NMDA channel activity to occur.
Original language | English (US) |
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Pages (from-to) | 325-327 |
Number of pages | 3 |
Journal | Brain Research |
Volume | 504 |
Issue number | 2 |
DOIs | |
State | Published - Dec 18 1989 |
Externally published | Yes |
Keywords
- 7-Chlorokynurenic acid
- Glycine receptor antagonist
- N-methyl-d-aspartate receptor
- Phencyclidine receptor
- [H]MK-801 binding
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)