Glycine Decarboxylase Cleaves a "Malignant" Metabolic Path to Promote Tumor Initiation

John E. Dominy, Francisca Vazquez, Pere Puigserver

Research output: Contribution to journalArticle


Tumor-initiating cells (TICs) are thought to be critical for promoting tumorigenesis. In a recent Cell article, Zhang and colleagues found that non-small cell lung cancer TICs overexpress the metabolic enzyme glycine decarboxylase, which leads to increases in pyrimidine synthesis and is critical for proliferation and tumor initiation.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalCancer Cell
Issue number2
StatePublished - Feb 14 2012
Externally publishedYes


ASJC Scopus subject areas

  • Cancer Research
  • Cell Biology
  • Oncology

Cite this