Glycine Decarboxylase Cleaves a "Malignant" Metabolic Path to Promote Tumor Initiation

John E. Dominy; Francisca Vazquez; Pere Puigserver

doi:10.1016/j.ccr.2012.01.019

Glycine Decarboxylase Cleaves a "Malignant" Metabolic Path to Promote Tumor Initiation

John E. Dominy, Francisca Vazquez, Pere Puigserver

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Tumor-initiating cells (TICs) are thought to be critical for promoting tumorigenesis. In a recent Cell article, Zhang and colleagues found that non-small cell lung cancer TICs overexpress the metabolic enzyme glycine decarboxylase, which leads to increases in pyrimidine synthesis and is critical for proliferation and tumor initiation.

Original language	English (US)
Pages (from-to)	143-145
Number of pages	3
Journal	Cancer Cell
Volume	21
Issue number	2
DOIs	https://doi.org/10.1016/j.ccr.2012.01.019
State	Published - Feb 14 2012
Externally published	Yes

ASJC Scopus subject areas

Cancer Research
Cell Biology
Oncology

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10.1016/j.ccr.2012.01.019

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abstract = "Tumor-initiating cells (TICs) are thought to be critical for promoting tumorigenesis. In a recent Cell article, Zhang and colleagues found that non-small cell lung cancer TICs overexpress the metabolic enzyme glycine decarboxylase, which leads to increases in pyrimidine synthesis and is critical for proliferation and tumor initiation.",

author = "Dominy, {John E.} and Francisca Vazquez and Pere Puigserver",

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AU - Dominy, John E.

AU - Vazquez, Francisca

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AB - Tumor-initiating cells (TICs) are thought to be critical for promoting tumorigenesis. In a recent Cell article, Zhang and colleagues found that non-small cell lung cancer TICs overexpress the metabolic enzyme glycine decarboxylase, which leads to increases in pyrimidine synthesis and is critical for proliferation and tumor initiation.

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Glycine Decarboxylase Cleaves a "Malignant" Metabolic Path to Promote Tumor Initiation

Abstract

ASJC Scopus subject areas

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