Glycemic modulation in neuro-oncology: Experience and future directions using a modified Atkins diet for high-grade brain tumors

Roy E. Strowd, Mackenzie Cervenka, Bobbie J. Henry, Eric H Kossoff, Adam L. Hartman, Jaishri Blakeley

Research output: Contribution to journalArticle

Abstract

Dietary glycemic modulation through high-fat, low-carbohydrate diets, which induce a state of systemic ketosis and alter systemic metabolic signaling, have been incorporated into the clinical management of patients with neurological disease for more than a century. Mounting preclinical evidence supports the antitumor, proapoptotic, and antiangiogenic effects of disrupting glycolytic metabolism through dietary intervention. In recent years, interest in incorporating such novel therapeutic strategies in neuro-oncology has increased. To date, 3 published studies incorporating novel dietary therapies in oncology have been reported, including one phase I study in neuro-oncology, and have set the stage for further study in this field. In this article, we review the biochemical pathways, preclinical data, and early clinical translation of dietary interventions that modulate systemic glycolytic metabolism in the management of primary malignant brain tumors. We introduce the modified Atkins diet (MAD), a novel dietary alternative to the classic ketogenic diet, and discuss the critical issues facing future study.

Original languageEnglish (US)
Pages (from-to)127-136
Number of pages10
JournalNeuro-Oncology Practice
Volume2
Issue number3
DOIs
Publication statusPublished - Jan 1 2015

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Keywords

  • Cancer metabolism
  • Glioma
  • Ketogenic diet
  • Modified Atkins diet
  • Seizure

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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