Glycemia and cognitive function in older adults using glucose-lowering drugs

R. I. Shorr, N. De Rekeneire, H. E. Resnick, K. Yaffe, G. W. Somes, A. M. Kanaya, Eleanor Marie Simonsick, A. B. Newman, T. B. Harris

Research output: Contribution to journalArticle

Abstract

Objectives: In experimental studies, both high and low levels of plasma glucose are associated with cognitive impairment. In populations, less is known about the relationship between glycemia and cognitive function, especially in persons using glucose-lowering drugs. Design: A cross-sectional study of 378 high-functioning black and white men and women aged 70 to 79 participating in the Health, Aging, and Body Composition Study (Health ABC) who used glucose-lowering medications. Glycemic measures included fasting plasma glucose (FPG) and glycosylated hemoglobin (HbA1c). Cognitive function was assessed using the Modified Mini-Mental State Examination (3MS) and the Digit Symbol Substitution Test (DSS) at the same examination visit in which the glycemic measures were determined. Setting: Memphis, Tennessee and Pittsburgh, Pennsylvania. Results: We observed an "inverted-U" relationship (p =.0025 for 3MS, p=.0277 for DSS) between FPG (range 47-366 mg/dl) and performance on these two tests. The fasting plasma glucose levels associated with the highest score on the 3MS was 180 mg/dl and 135 mg/dl for the DSS. There was a monotonic inverse relationship between HbA1c and performance on 3MS and DSS without evidence of a threshold effect. Conclusion: Our findings suggest that older adults who are treated for diabetes may experience a small degree of cognitive impairment within the recommended fasting glucose levels, yet measures of long-term glycemic control support tight glycemic control. Given the high prevalence of diabetes and the common use of glucose-lowering drugs in older adults, further studies are needed to elucidate these relationships. The Journal of Nutrition, Health & Aging

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalThe journal of nutrition, health & aging
Volume10
Issue number4
StatePublished - Jul 2006
Externally publishedYes

Fingerprint

cognition
Cognition
blood glucose
Glucose
drugs
glucose
Pharmaceutical Preparations
fasting
Fasting
glycemic control
glycohemoglobin
testing
diabetes
Health
Glycosylated Hemoglobin A
Body Composition
cross-sectional studies
drug therapy
body composition
hemoglobin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Aging
  • Endocrinology
  • Food Science

Cite this

Shorr, R. I., De Rekeneire, N., Resnick, H. E., Yaffe, K., Somes, G. W., Kanaya, A. M., ... Harris, T. B. (2006). Glycemia and cognitive function in older adults using glucose-lowering drugs. The journal of nutrition, health & aging, 10(4), 297-301.

Glycemia and cognitive function in older adults using glucose-lowering drugs. / Shorr, R. I.; De Rekeneire, N.; Resnick, H. E.; Yaffe, K.; Somes, G. W.; Kanaya, A. M.; Simonsick, Eleanor Marie; Newman, A. B.; Harris, T. B.

In: The journal of nutrition, health & aging, Vol. 10, No. 4, 07.2006, p. 297-301.

Research output: Contribution to journalArticle

Shorr, RI, De Rekeneire, N, Resnick, HE, Yaffe, K, Somes, GW, Kanaya, AM, Simonsick, EM, Newman, AB & Harris, TB 2006, 'Glycemia and cognitive function in older adults using glucose-lowering drugs', The journal of nutrition, health & aging, vol. 10, no. 4, pp. 297-301.
Shorr RI, De Rekeneire N, Resnick HE, Yaffe K, Somes GW, Kanaya AM et al. Glycemia and cognitive function in older adults using glucose-lowering drugs. The journal of nutrition, health & aging. 2006 Jul;10(4):297-301.
Shorr, R. I. ; De Rekeneire, N. ; Resnick, H. E. ; Yaffe, K. ; Somes, G. W. ; Kanaya, A. M. ; Simonsick, Eleanor Marie ; Newman, A. B. ; Harris, T. B. / Glycemia and cognitive function in older adults using glucose-lowering drugs. In: The journal of nutrition, health & aging. 2006 ; Vol. 10, No. 4. pp. 297-301.
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AU - Somes, G. W.

AU - Kanaya, A. M.

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