Glyburide is associated with attenuated vasogenic edema in stroke patients

W. Taylor Kimberly, Thomas W.K. Battey, Ly Pham, Ona Wu, Albert J. Yoo, Karen L. Furie, Aneesh B. Singhal, Jordan J. Elm, Barney J. Stern, Kevin N. Sheth

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Brain edema is a serious complication of ischemic stroke that can lead to secondary neurological deterioration and death. Glyburide is reported to prevent brain swelling in preclinical rodent models of ischemic stroke through inhibition of a non-selective channel composed of sulfonylurea receptor 1 and transient receptor potential cation channel subfamily M member 4. However, the relevance of this pathway to the development of cerebral edema in stroke patients is not known. Methods: Using a case-control design, we retrospectively assessed neuroimaging and blood markers of cytotoxic and vasogenic edema in subjects who were enrolled in the glyburide advantage in malignant edema and stroke-pilot (GAMES-Pilot) trial. We compared serial brain magnetic resonance images (MRIs) to a cohort with similar large volume infarctions. We also compared matrix metalloproteinase-9 (MMP-9) plasma level in large hemispheric stroke. Results: We report that IV glyburide was associated with T2 fluid-attenuated inversion recovery signal intensity ratio on brain MRI, diminished the lesional water diffusivity between days 1 and 2 (pseudo-normalization), and reduced blood MMP-9 level. Conclusions: Several surrogate markers of vasogenic edema appear to be reduced in the setting of IV glyburide treatment in human stroke. Verification of these potential imaging and blood biomarkers is warranted in the context of a randomized, placebo-controlled trial.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalNeurocritical care
Volume20
Issue number2
DOIs
StatePublished - Apr 2014
Externally publishedYes

Keywords

  • Biomarker
  • Cerebral edema
  • Glyburide
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine

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