Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans

Jean G. Ford, Yongliang Li, Mary Margaret O'Sullivan, Rita Demopoulos, Seymour Garte, Emanuela Taioli, Paul W. Brandt-Rauf

Research output: Contribution to journalArticle

Abstract

Glutathione S-transferase M1 (GSTM1) can detoxify many carcinogens, including polycyclic aromatic hydrocarbons such as those from cigarette smoke. Though a number of studies have been published about the association between GSTM1 polymorphism and lung cancer, this association has received limited attention in the African-American population. We conducted a case-control study to investigate the role of GSTM1 polymorphism in the development of lung cancer in African-Americans. Specimens of DNA from 117 lung cancer cases and 120 controls were assayed for detection of GSTM1 genotype by polymerase chain reaction (PCR). The odds ratios (ORs) and 95% confidence intervals (CIs) for lung cancer associated with homozygous deletion of the GSTM1 gene and other risk factors were estimated by logistic regression. Thirty-seven of the 117 cases (31.6%) and 24 of the 120 controls (20.0%) had the GSTM1 null genotype; the OR was 2.10 (95% CI 1.07-4.11) after adjustment for age, gender and smoking. The association was higher for squamous cell carcinoma (OR 2.98, 95% CI 1.09-8.19) than for adenocarcinoma (OR 1.95, 95% CI 0.81-4.66). We observed a stronger association between GSTM1 null genotype and lung cancer among heavy smokers with ≥30 pack-years (OR 4.35, 95% CI 1.16-16.23). This association was also found in squamous cell carcinoma (OR 6.26, 95% CI 1.31-29.91). In the analysis combining GSTM1 polymorphism and smoking, smokers with the null genotype had high risk (OR 8.19, 95% CI 2.35-28.62) compared with non-smokers with the wild-type genotype, and the risk increased with smoking cigarette pack-years (P = 0.0001 for trend). Our results suggest that GSTM1 polymorphism plays a role in the development of lung cancer and modifies the risk for smoking-related lung cancer in African-Americans.

Original languageEnglish (US)
Pages (from-to)1971-1975
Number of pages5
JournalCarcinogenesis
Volume21
Issue number11
StatePublished - 2000
Externally publishedYes

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African Americans
Lung Neoplasms
Odds Ratio
Confidence Intervals
Genotype
Smoking
Squamous Cell Carcinoma
glutathione S-transferase M1
Polycyclic Aromatic Hydrocarbons
Smoke
Tobacco Products
Carcinogens
Case-Control Studies
Adenocarcinoma
Logistic Models
Polymerase Chain Reaction
DNA
Population
Genes

ASJC Scopus subject areas

  • Cancer Research

Cite this

Ford, J. G., Li, Y., O'Sullivan, M. M., Demopoulos, R., Garte, S., Taioli, E., & Brandt-Rauf, P. W. (2000). Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans. Carcinogenesis, 21(11), 1971-1975.

Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans. / Ford, Jean G.; Li, Yongliang; O'Sullivan, Mary Margaret; Demopoulos, Rita; Garte, Seymour; Taioli, Emanuela; Brandt-Rauf, Paul W.

In: Carcinogenesis, Vol. 21, No. 11, 2000, p. 1971-1975.

Research output: Contribution to journalArticle

Ford, JG, Li, Y, O'Sullivan, MM, Demopoulos, R, Garte, S, Taioli, E & Brandt-Rauf, PW 2000, 'Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans', Carcinogenesis, vol. 21, no. 11, pp. 1971-1975.
Ford JG, Li Y, O'Sullivan MM, Demopoulos R, Garte S, Taioli E et al. Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans. Carcinogenesis. 2000;21(11):1971-1975.
Ford, Jean G. ; Li, Yongliang ; O'Sullivan, Mary Margaret ; Demopoulos, Rita ; Garte, Seymour ; Taioli, Emanuela ; Brandt-Rauf, Paul W. / Glutathione S-transferase M1 polymorphism and lung cancer risk in African-Americans. In: Carcinogenesis. 2000 ; Vol. 21, No. 11. pp. 1971-1975.
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abstract = "Glutathione S-transferase M1 (GSTM1) can detoxify many carcinogens, including polycyclic aromatic hydrocarbons such as those from cigarette smoke. Though a number of studies have been published about the association between GSTM1 polymorphism and lung cancer, this association has received limited attention in the African-American population. We conducted a case-control study to investigate the role of GSTM1 polymorphism in the development of lung cancer in African-Americans. Specimens of DNA from 117 lung cancer cases and 120 controls were assayed for detection of GSTM1 genotype by polymerase chain reaction (PCR). The odds ratios (ORs) and 95{\%} confidence intervals (CIs) for lung cancer associated with homozygous deletion of the GSTM1 gene and other risk factors were estimated by logistic regression. Thirty-seven of the 117 cases (31.6{\%}) and 24 of the 120 controls (20.0{\%}) had the GSTM1 null genotype; the OR was 2.10 (95{\%} CI 1.07-4.11) after adjustment for age, gender and smoking. The association was higher for squamous cell carcinoma (OR 2.98, 95{\%} CI 1.09-8.19) than for adenocarcinoma (OR 1.95, 95{\%} CI 0.81-4.66). We observed a stronger association between GSTM1 null genotype and lung cancer among heavy smokers with ≥30 pack-years (OR 4.35, 95{\%} CI 1.16-16.23). This association was also found in squamous cell carcinoma (OR 6.26, 95{\%} CI 1.31-29.91). In the analysis combining GSTM1 polymorphism and smoking, smokers with the null genotype had high risk (OR 8.19, 95{\%} CI 2.35-28.62) compared with non-smokers with the wild-type genotype, and the risk increased with smoking cigarette pack-years (P = 0.0001 for trend). Our results suggest that GSTM1 polymorphism plays a role in the development of lung cancer and modifies the risk for smoking-related lung cancer in African-Americans.",
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