Glutathione levels and immune responses in tuberculosis patients

Vishwanath Venketaraman, Ariel Millman, Marwa Salman, Shobha Swaminathan, Mary Goetz, Alfred Lardizabal, Hom David Hom, Nancy Connell

Research output: Contribution to journalArticle

Abstract

Glutathione levels are significantly reduced in peripheral blood mononuclear cells and red blood cells isolated from tuberculosis patients. Treatment of blood cultures from tuberculosis patients with N-acetyl cysteine, a glutathione precursor, was associated with improved control of intracellular M. tuberculosis infection. N-acetyl-cysteine treatment decreased the levels of IL-10, IL-6, TNF-α and IL-1, in blood cultures derived from tuberculosis patients, favoring the host immune cells to successfully control M. tuberculosis replication.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalMicrobial Pathogenesis
Volume44
Issue number3
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

Fingerprint

Glutathione
Tuberculosis
Cysteine
Interleukin-1
Interleukin-10
Interleukin-6
Blood Cells
Erythrocytes
Therapeutics
Infection
Blood Culture

Keywords

  • Glutathione
  • Tuberculosis immunity

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

Venketaraman, V., Millman, A., Salman, M., Swaminathan, S., Goetz, M., Lardizabal, A., ... Connell, N. (2008). Glutathione levels and immune responses in tuberculosis patients. Microbial Pathogenesis, 44(3), 255-261. https://doi.org/10.1016/j.micpath.2007.09.002

Glutathione levels and immune responses in tuberculosis patients. / Venketaraman, Vishwanath; Millman, Ariel; Salman, Marwa; Swaminathan, Shobha; Goetz, Mary; Lardizabal, Alfred; David Hom, Hom; Connell, Nancy.

In: Microbial Pathogenesis, Vol. 44, No. 3, 01.03.2008, p. 255-261.

Research output: Contribution to journalArticle

Venketaraman, V, Millman, A, Salman, M, Swaminathan, S, Goetz, M, Lardizabal, A, David Hom, H & Connell, N 2008, 'Glutathione levels and immune responses in tuberculosis patients', Microbial Pathogenesis, vol. 44, no. 3, pp. 255-261. https://doi.org/10.1016/j.micpath.2007.09.002
Venketaraman V, Millman A, Salman M, Swaminathan S, Goetz M, Lardizabal A et al. Glutathione levels and immune responses in tuberculosis patients. Microbial Pathogenesis. 2008 Mar 1;44(3):255-261. https://doi.org/10.1016/j.micpath.2007.09.002
Venketaraman, Vishwanath ; Millman, Ariel ; Salman, Marwa ; Swaminathan, Shobha ; Goetz, Mary ; Lardizabal, Alfred ; David Hom, Hom ; Connell, Nancy. / Glutathione levels and immune responses in tuberculosis patients. In: Microbial Pathogenesis. 2008 ; Vol. 44, No. 3. pp. 255-261.
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