Glutathione levels and immune responses in tuberculosis patients

Vishwanath Venketaraman, Ariel Millman, Marwa Salman, Shobha Swaminathan, Mary Goetz, Alfred Lardizabal, Hom David Hom, Nancy D. Connell

Research output: Contribution to journalArticle

Abstract

Glutathione levels are significantly reduced in peripheral blood mononuclear cells and red blood cells isolated from tuberculosis patients. Treatment of blood cultures from tuberculosis patients with N-acetyl cysteine, a glutathione precursor, was associated with improved control of intracellular M. tuberculosis infection. N-acetyl-cysteine treatment decreased the levels of IL-10, IL-6, TNF-α and IL-1, in blood cultures derived from tuberculosis patients, favoring the host immune cells to successfully control M. tuberculosis replication.

Original languageEnglish (US)
Pages (from-to)255-261
Number of pages7
JournalMicrobial Pathogenesis
Volume44
Issue number3
DOIs
StatePublished - Mar 1 2008
Externally publishedYes

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Keywords

  • Glutathione
  • Tuberculosis immunity

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

Cite this

Venketaraman, V., Millman, A., Salman, M., Swaminathan, S., Goetz, M., Lardizabal, A., David Hom, H., & Connell, N. D. (2008). Glutathione levels and immune responses in tuberculosis patients. Microbial Pathogenesis, 44(3), 255-261. https://doi.org/10.1016/j.micpath.2007.09.002