Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

Chi V. Dang

Research output: Contribution to journalArticlepeer-review

Abstract

A cancer cell comprising largely of carbon, hydrogen, oxygen, phosphorus, nitrogen and sulfur requires not only glucose, which is avidly transported and converted to lactate by aerobic glycolysis or the Warburg effect, but also glutamine as a major substrate. Glutamine and essential amino acids, such as methionine, provide energy through the TCA cycle as well as nitrogen, sulfur and carbon skeletons for growing and proliferating cancer cells. The interplay between utilization of glutamine and glucose is likely to depend on the genetic make-up of a cancer cell. While the MYC oncogene induces both aerobic glycolysis and glutaminolysis, activated β-catenin induces glutamine synthesis in hepatocellular carcinoma. Cancer cells that have elevated glutamine synthetase can use glutamate and ammonia to synthesize glutamine and are hence not addicted to glutamine. As such, cancer cells have many degrees of freedom for re-programming cell metabolism, which with better understanding will result in novel therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)3884-3886
Number of pages3
JournalCell cycle (Georgetown, Tex.)
Volume9
Issue number19
DOIs
StatePublished - Oct 1 2010

Keywords

  • Aerobic glycolysis
  • Ammonia
  • Cancer metabolism
  • Glutaminase
  • Glutamine synthetase
  • Glutaminolysis

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Developmental Biology

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