Glutamine synthetase inhibition prevents cerebral oedema during hyperammonemia.

H. Takahashi, Raymond C Koehler, S. W. Brusilow, R. J. Traystman

Research output: Contribution to journalArticle

Abstract

The relationship between cerebral oedema and cerebral glutamine accumulation was investigated during acute hyperammonemia in anesthetized rats. Six hours of ammonium acetate infusion resulted in an increase in cortical glutamine concentration and a decrease in specific gravity. Pretreatment with methionine sulfoximine inhibited glutamine synthetase, prevented the increase in glutamine during hyperammonemia, and prevented the decrease in specific gravity. We conclude that the increase in brain water content is linked to the glutamine accumulation derived from the detoxification of ammonia by glutamine synthetase.

Original languageEnglish (US)
Pages (from-to)346-347
Number of pages2
JournalActa Neurochirurgica, Supplement
Volume51
StatePublished - 1990

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Hyperammonemia
Glutamate-Ammonia Ligase
Brain Edema
Glutamine
Specific Gravity
Methionine Sulfoximine
Ammonia
Water
Brain

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Glutamine synthetase inhibition prevents cerebral oedema during hyperammonemia. / Takahashi, H.; Koehler, Raymond C; Brusilow, S. W.; Traystman, R. J.

In: Acta Neurochirurgica, Supplement, Vol. 51, 1990, p. 346-347.

Research output: Contribution to journalArticle

Takahashi, H. ; Koehler, Raymond C ; Brusilow, S. W. ; Traystman, R. J. / Glutamine synthetase inhibition prevents cerebral oedema during hyperammonemia. In: Acta Neurochirurgica, Supplement. 1990 ; Vol. 51. pp. 346-347.
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