Glutamine synthetase inhibition prevents cerebral oedema during hyperammonemia.

H. Takahashi; R. C. Koehler; S. W. Brusilow; R. J. Traystman

doi:10.1007/978-3-7091-9115-6_117

Glutamine synthetase inhibition prevents cerebral oedema during hyperammonemia.

H. Takahashi, R. C. Koehler, S. W. Brusilow, R. J. Traystman

School of Medicine

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The relationship between cerebral oedema and cerebral glutamine accumulation was investigated during acute hyperammonemia in anesthetized rats. Six hours of ammonium acetate infusion resulted in an increase in cortical glutamine concentration and a decrease in specific gravity. Pretreatment with methionine sulfoximine inhibited glutamine synthetase, prevented the increase in glutamine during hyperammonemia, and prevented the decrease in specific gravity. We conclude that the increase in brain water content is linked to the glutamine accumulation derived from the detoxification of ammonia by glutamine synthetase.

Original language	English (US)
Pages (from-to)	346-347
Number of pages	2
Journal	Acta neurochirurgica. Supplementum
Volume	51
DOIs	https://doi.org/10.1007/978-3-7091-9115-6_117
State	Published - 1990

ASJC Scopus subject areas

Surgery
Clinical Neurology

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abstract = "The relationship between cerebral oedema and cerebral glutamine accumulation was investigated during acute hyperammonemia in anesthetized rats. Six hours of ammonium acetate infusion resulted in an increase in cortical glutamine concentration and a decrease in specific gravity. Pretreatment with methionine sulfoximine inhibited glutamine synthetase, prevented the increase in glutamine during hyperammonemia, and prevented the decrease in specific gravity. We conclude that the increase in brain water content is linked to the glutamine accumulation derived from the detoxification of ammonia by glutamine synthetase.",

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AU - Brusilow, S. W.

AU - Traystman, R. J.

PY - 1990

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N2 - The relationship between cerebral oedema and cerebral glutamine accumulation was investigated during acute hyperammonemia in anesthetized rats. Six hours of ammonium acetate infusion resulted in an increase in cortical glutamine concentration and a decrease in specific gravity. Pretreatment with methionine sulfoximine inhibited glutamine synthetase, prevented the increase in glutamine during hyperammonemia, and prevented the decrease in specific gravity. We conclude that the increase in brain water content is linked to the glutamine accumulation derived from the detoxification of ammonia by glutamine synthetase.

AB - The relationship between cerebral oedema and cerebral glutamine accumulation was investigated during acute hyperammonemia in anesthetized rats. Six hours of ammonium acetate infusion resulted in an increase in cortical glutamine concentration and a decrease in specific gravity. Pretreatment with methionine sulfoximine inhibited glutamine synthetase, prevented the increase in glutamine during hyperammonemia, and prevented the decrease in specific gravity. We conclude that the increase in brain water content is linked to the glutamine accumulation derived from the detoxification of ammonia by glutamine synthetase.

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ER -

Glutamine synthetase inhibition prevents cerebral oedema during hyperammonemia.

Abstract

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