Glutamine metabolism in metabolic acidosis.

G. A. Alleyne, J. A. Lupianez, N. McFarlane-Anderson, P. Hortelano, J. Benjamin, J. Barnswell, B. Scott

Research output: Contribution to journalArticle

Abstract

In chronic metabolic acidosis in the rat, there is increased ammoniagenesis, gluconeogenesis and renal extraction of glutamine with induction of renal phosphate-dependent glutaminase (PDG). Because the stimulus for these changes is not yet clear and also because acute acidosis is the more common clinical problem, the present study deals mainly with the metabolism of glutamine in acute metabolic acidosis. When acute metabolic acidosis is produced in rats by administration of mineral acid or by causing them to swim, thus inducing a severe lactic acidosis, a factor is found in the plasma which stimulates renal glutamine uptake and ammoniagenesis in vivo as well as in vitro. Acute acidosis does not induce synthesis of PDG in the kidney but causes a change in enzyme kinetics. The plasma factor not only enhances glutamine entry into cells, but apparently causes a conformational change in PDG, as shown by an increase in V1.0mM/Vmax. Intestinal metabolism of glutamine is also stimulated in vivo and in vitro by the plasma factor of acute acidosis.

Original languageEnglish (US)
Pages (from-to)101-119
Number of pages19
JournalCiba Foundation symposium
Volume87
StatePublished - 1982
Externally publishedYes

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Acidosis
Glutamine
Glutaminase
Kidney
Phosphates
Lactic Acidosis
Gluconeogenesis
Minerals
Acids
Enzymes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Alleyne, G. A., Lupianez, J. A., McFarlane-Anderson, N., Hortelano, P., Benjamin, J., Barnswell, J., & Scott, B. (1982). Glutamine metabolism in metabolic acidosis. Ciba Foundation symposium, 87, 101-119.

Glutamine metabolism in metabolic acidosis. / Alleyne, G. A.; Lupianez, J. A.; McFarlane-Anderson, N.; Hortelano, P.; Benjamin, J.; Barnswell, J.; Scott, B.

In: Ciba Foundation symposium, Vol. 87, 1982, p. 101-119.

Research output: Contribution to journalArticle

Alleyne, GA, Lupianez, JA, McFarlane-Anderson, N, Hortelano, P, Benjamin, J, Barnswell, J & Scott, B 1982, 'Glutamine metabolism in metabolic acidosis.', Ciba Foundation symposium, vol. 87, pp. 101-119.
Alleyne GA, Lupianez JA, McFarlane-Anderson N, Hortelano P, Benjamin J, Barnswell J et al. Glutamine metabolism in metabolic acidosis. Ciba Foundation symposium. 1982;87:101-119.
Alleyne, G. A. ; Lupianez, J. A. ; McFarlane-Anderson, N. ; Hortelano, P. ; Benjamin, J. ; Barnswell, J. ; Scott, B. / Glutamine metabolism in metabolic acidosis. In: Ciba Foundation symposium. 1982 ; Vol. 87. pp. 101-119.
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