Glutamine metabolism in cancer

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Dysregulation of the TCA cycle and glutamine addiction are characteristic features of glutamine metabolism in cancers.Targeting glutamine metabolism in cancer includes inhibition of glutaminolysis by glutaminase inhibitors, combination therapy, knockdown of c-MYC, inhibition of GDH, depletion of glutamine supply, inhibition of glutamine uptake, and usage of glutamine analogs.Transaminase upregulation and targeting amino acid synthesis have potential for cancer therapy.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages13-32
Number of pages20
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1063
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Glutamine addiction
  • Glutamine metabolism
  • Targeting amino acid synthesis
  • Targeting glutamine metabolism
  • Transaminase upregulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Li, T., & Le Thi, Q. H. (2018). Glutamine metabolism in cancer. In Advances in Experimental Medicine and Biology (pp. 13-32). (Advances in Experimental Medicine and Biology; Vol. 1063). Springer New York LLC. https://doi.org/10.1007/978-3-319-77736-8_2