Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques

Lary C. Walker, Cheryl A. Kitt, Robert G. Struble, Donald E. Schmechel, Wolfgang H. Oertel, Linda C. Cork, Donald L. Price

Research output: Contribution to journalArticle

Abstract

In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that γ-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalNeuroscience Letters
Volume59
Issue number2
DOIs
StatePublished - Aug 30 1985

Fingerprint

Aminobutyrates
Glutamate Decarboxylase
Neocortex
Amyloid Plaques
Neurites
Macaca mulatta
Amyloid
Neurons
Brain

Keywords

  • aging
  • Alzheimer's disease
  • glutamic acid decarboxylase
  • immunocytochemistry
  • monkey
  • senile plaque

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Walker, L. C., Kitt, C. A., Struble, R. G., Schmechel, D. E., Oertel, W. H., Cork, L. C., & Price, D. L. (1985). Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques. Neuroscience Letters, 59(2), 165-169. https://doi.org/10.1016/0304-3940(85)90194-6

Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques. / Walker, Lary C.; Kitt, Cheryl A.; Struble, Robert G.; Schmechel, Donald E.; Oertel, Wolfgang H.; Cork, Linda C.; Price, Donald L.

In: Neuroscience Letters, Vol. 59, No. 2, 30.08.1985, p. 165-169.

Research output: Contribution to journalArticle

Walker, LC, Kitt, CA, Struble, RG, Schmechel, DE, Oertel, WH, Cork, LC & Price, DL 1985, 'Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques', Neuroscience Letters, vol. 59, no. 2, pp. 165-169. https://doi.org/10.1016/0304-3940(85)90194-6
Walker LC, Kitt CA, Struble RG, Schmechel DE, Oertel WH, Cork LC et al. Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques. Neuroscience Letters. 1985 Aug 30;59(2):165-169. https://doi.org/10.1016/0304-3940(85)90194-6
Walker, Lary C. ; Kitt, Cheryl A. ; Struble, Robert G. ; Schmechel, Donald E. ; Oertel, Wolfgang H. ; Cork, Linda C. ; Price, Donald L. / Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques. In: Neuroscience Letters. 1985 ; Vol. 59, No. 2. pp. 165-169.
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