Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques

Lary C. Walker, Cheryl A. Kitt, Robert G. Struble, Donald E. Schmechel, Wolfgang H. Oertel, Linda C. Cork, Donald L. Price

Research output: Contribution to journalArticlepeer-review

Abstract

In the neocortex of an aged (26-year-old) rhesus monkey, a small percentage of abnormal neurites within some senile plaques (defined by the presence of amyloid) were immunoreactive for glutamic acid decarboxylase. This suggests that γ-aminobutyric acid-synthesizing neurons may contribute to plaque formation in the aged brain.

Original languageEnglish (US)
Pages (from-to)165-169
Number of pages5
JournalNeuroscience Letters
Volume59
Issue number2
DOIs
StatePublished - Aug 30 1985

Keywords

  • aging
  • Alzheimer's disease
  • glutamic acid decarboxylase
  • immunocytochemistry
  • monkey
  • senile plaque

ASJC Scopus subject areas

  • Neuroscience(all)

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