Abstract
Glutamic acid decarboxylase (GAD) activity was measured in the cerebral cortex of animals after acute and chronic lesions to basal forebrain cholinergic nuclei. Such lesions were shown to result in an extensive depletion of cholinergic markers in parietal cerebral cortex. A statistically significant 30% decrease in GAD activity was first detected at 6 weeks postlesion and was still measurable 8 months after the lesion. These results suggest that cholinergic inputs to cortex indirectly or directly influence GABAergic transmission in cortex.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 165-168 |
| Number of pages | 4 |
| Journal | Brain Research |
| Volume | 333 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 29 1985 |
| Externally published | Yes |
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Keywords
- basal forebrain lesion
- glutamic acid decarboxylase (GAD)
- mouse cortex
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)
Cite this
Glutamic acid decarboxylase activity decreases in mouse neocortex after lesions of the basal forebrain. / Hohmann, Christine F.; Bear, M. F.; Ebner, F. F.
In: Brain Research, Vol. 333, No. 1, 29.04.1985, p. 165-168.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Glutamic acid decarboxylase activity decreases in mouse neocortex after lesions of the basal forebrain
AU - Hohmann, Christine F.
AU - Bear, M. F.
AU - Ebner, F. F.
PY - 1985/4/29
Y1 - 1985/4/29
N2 - Glutamic acid decarboxylase (GAD) activity was measured in the cerebral cortex of animals after acute and chronic lesions to basal forebrain cholinergic nuclei. Such lesions were shown to result in an extensive depletion of cholinergic markers in parietal cerebral cortex. A statistically significant 30% decrease in GAD activity was first detected at 6 weeks postlesion and was still measurable 8 months after the lesion. These results suggest that cholinergic inputs to cortex indirectly or directly influence GABAergic transmission in cortex.
AB - Glutamic acid decarboxylase (GAD) activity was measured in the cerebral cortex of animals after acute and chronic lesions to basal forebrain cholinergic nuclei. Such lesions were shown to result in an extensive depletion of cholinergic markers in parietal cerebral cortex. A statistically significant 30% decrease in GAD activity was first detected at 6 weeks postlesion and was still measurable 8 months after the lesion. These results suggest that cholinergic inputs to cortex indirectly or directly influence GABAergic transmission in cortex.
KW - basal forebrain lesion
KW - glutamic acid decarboxylase (GAD)
KW - mouse cortex
UR - http://www.scopus.com/inward/record.url?scp=0021996524&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021996524&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(85)90139-8
DO - 10.1016/0006-8993(85)90139-8
M3 - Article
C2 - 2986770
AN - SCOPUS:0021996524
VL - 333
SP - 165
EP - 168
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1
ER -