Glutamic acid decarboxylase activity decreases in mouse neocortex after lesions of the basal forebrain

C. F. Höhmann, M. F. Bear, F. F. Ebner

Research output: Contribution to journalArticlepeer-review

Abstract

Glutamic acid decarboxylase (GAD) activity was measured in the cerebral cortex of animals after acute and chronic lesions to basal forebrain cholinergic nuclei. Such lesions were shown to result in an extensive depletion of cholinergic markers in parietal cerebral cortex. A statistically significant 30% decrease in GAD activity was first detected at 6 weeks postlesion and was still measurable 8 months after the lesion. These results suggest that cholinergic inputs to cortex indirectly or directly influence GABAergic transmission in cortex.

Original languageEnglish (US)
Pages (from-to)165-168
Number of pages4
JournalBrain research
Volume333
Issue number1
DOIs
StatePublished - Apr 29 1985
Externally publishedYes

Keywords

  • basal forebrain lesion
  • glutamic acid decarboxylase (GAD)
  • mouse cortex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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