Abstract
Glutamic acid decarboxylase (GAD) activity was measured in the cerebral cortex of animals after acute and chronic lesions to basal forebrain cholinergic nuclei. Such lesions were shown to result in an extensive depletion of cholinergic markers in parietal cerebral cortex. A statistically significant 30% decrease in GAD activity was first detected at 6 weeks postlesion and was still measurable 8 months after the lesion. These results suggest that cholinergic inputs to cortex indirectly or directly influence GABAergic transmission in cortex.
Original language | English (US) |
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Pages (from-to) | 165-168 |
Number of pages | 4 |
Journal | Brain research |
Volume | 333 |
Issue number | 1 |
DOIs | |
State | Published - Apr 29 1985 |
Externally published | Yes |
Keywords
- basal forebrain lesion
- glutamic acid decarboxylase (GAD)
- mouse cortex
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology