Glutamatergic synaptic input to glioma cells drives brain tumour progression

Varun Venkataramani, Dimitar Ivanov Tanev, Christopher Strahle, Alexander Studier-Fischer, Laura Fankhauser, Tobias Kessler, Christoph Körber, Markus Kardorff, Miriam Ratliff, Ruifan Xie, Heinz Horstmann, Mirko Messer, Sang Peter Paik, Johannes Knabbe, Felix Sahm, Felix T. Kurz, Azer Aylin Acikgöz, Frank Herrmannsdörfer, Amit Agarwal, Dwight E. BerglesAnthony Chalmers, Hrvoje Miletic, Sevin Turcan, Christian Mawrin, Daniel Hänggi, Hai Kun Liu, Wolfgang Wick, Frank Winkler, Thomas Kuner

Research output: Contribution to journalArticle

Abstract

A network of communicating tumour cells that is connected by tumour microtubes mediates the progression of incurable gliomas. Moreover, neuronal activity can foster malignant behaviour of glioma cells by non-synaptic paracrine and autocrine mechanisms. Here we report a direct communication channel between neurons and glioma cells in different disease models and human tumours: functional bona fide chemical synapses between presynaptic neurons and postsynaptic glioma cells. These neurogliomal synapses show a typical synaptic ultrastructure, are located on tumour microtubes, and produce postsynaptic currents that are mediated by glutamate receptors of the AMPA subtype. Neuronal activity including epileptic conditions generates synchronised calcium transients in tumour-microtube-connected glioma networks. Glioma-cell-specific genetic perturbation of AMPA receptors reduces calcium-related invasiveness of tumour-microtube-positive tumour cells and glioma growth. Invasion and growth are also reduced by anaesthesia and the AMPA receptor antagonist perampanel, respectively. These findings reveal a biologically relevant direct synaptic communication between neurons and glioma cells with potential clinical implications.

Original languageEnglish (US)
Pages (from-to)532-538
Number of pages7
JournalNature
Volume573
Issue number7775
DOIs
StatePublished - Sep 26 2019
Externally publishedYes

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Brain Neoplasms
Glioma
Neoplasms
AMPA Receptors
Neurons
Synapses
Communication
Calcium
Synaptic Potentials
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Drive
Glutamate Receptors
Growth
Anesthesia

ASJC Scopus subject areas

  • General

Cite this

Venkataramani, V., Tanev, D. I., Strahle, C., Studier-Fischer, A., Fankhauser, L., Kessler, T., ... Kuner, T. (2019). Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature, 573(7775), 532-538. https://doi.org/10.1038/s41586-019-1564-x

Glutamatergic synaptic input to glioma cells drives brain tumour progression. / Venkataramani, Varun; Tanev, Dimitar Ivanov; Strahle, Christopher; Studier-Fischer, Alexander; Fankhauser, Laura; Kessler, Tobias; Körber, Christoph; Kardorff, Markus; Ratliff, Miriam; Xie, Ruifan; Horstmann, Heinz; Messer, Mirko; Paik, Sang Peter; Knabbe, Johannes; Sahm, Felix; Kurz, Felix T.; Acikgöz, Azer Aylin; Herrmannsdörfer, Frank; Agarwal, Amit; Bergles, Dwight E.; Chalmers, Anthony; Miletic, Hrvoje; Turcan, Sevin; Mawrin, Christian; Hänggi, Daniel; Liu, Hai Kun; Wick, Wolfgang; Winkler, Frank; Kuner, Thomas.

In: Nature, Vol. 573, No. 7775, 26.09.2019, p. 532-538.

Research output: Contribution to journalArticle

Venkataramani, V, Tanev, DI, Strahle, C, Studier-Fischer, A, Fankhauser, L, Kessler, T, Körber, C, Kardorff, M, Ratliff, M, Xie, R, Horstmann, H, Messer, M, Paik, SP, Knabbe, J, Sahm, F, Kurz, FT, Acikgöz, AA, Herrmannsdörfer, F, Agarwal, A, Bergles, DE, Chalmers, A, Miletic, H, Turcan, S, Mawrin, C, Hänggi, D, Liu, HK, Wick, W, Winkler, F & Kuner, T 2019, 'Glutamatergic synaptic input to glioma cells drives brain tumour progression', Nature, vol. 573, no. 7775, pp. 532-538. https://doi.org/10.1038/s41586-019-1564-x
Venkataramani V, Tanev DI, Strahle C, Studier-Fischer A, Fankhauser L, Kessler T et al. Glutamatergic synaptic input to glioma cells drives brain tumour progression. Nature. 2019 Sep 26;573(7775):532-538. https://doi.org/10.1038/s41586-019-1564-x
Venkataramani, Varun ; Tanev, Dimitar Ivanov ; Strahle, Christopher ; Studier-Fischer, Alexander ; Fankhauser, Laura ; Kessler, Tobias ; Körber, Christoph ; Kardorff, Markus ; Ratliff, Miriam ; Xie, Ruifan ; Horstmann, Heinz ; Messer, Mirko ; Paik, Sang Peter ; Knabbe, Johannes ; Sahm, Felix ; Kurz, Felix T. ; Acikgöz, Azer Aylin ; Herrmannsdörfer, Frank ; Agarwal, Amit ; Bergles, Dwight E. ; Chalmers, Anthony ; Miletic, Hrvoje ; Turcan, Sevin ; Mawrin, Christian ; Hänggi, Daniel ; Liu, Hai Kun ; Wick, Wolfgang ; Winkler, Frank ; Kuner, Thomas. / Glutamatergic synaptic input to glioma cells drives brain tumour progression. In: Nature. 2019 ; Vol. 573, No. 7775. pp. 532-538.
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