Glutamate and Glycine Binding to the NMDA Receptor

Alvin Yu, Albert Y. Lau

Research output: Contribution to journalArticle

Abstract

In the N-methyl-D-aspartic acid receptor family of ionotropic glutamate receptors, the agonist glutamate and its co-agonist glycine bind to their respective subunits by different dynamic mechanisms. Glutamate binding is assisted by structural features on the receptor surface. Glycine binding does not receive such assistance.

Original languageEnglish (US)
Pages (from-to)1035-1043.e2
JournalStructure
Volume26
Issue number7
DOIs
StatePublished - Jul 3 2018

Keywords

  • NMDA receptors
  • free energy calculations
  • glutamate receptors
  • ligand binding
  • molecular dynamics simulations

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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