Glucose vs sucrose in oral rehydration solutions for infants and young children with rotavirus-associated diarrhea

R. E. Black, M. H. Merson, P. R. Taylor, R. H. Yolken, D. A. Sack

Research output: Contribution to journalArticlepeer-review

Abstract

The use of oral dehydration solutions containing essential electrolytes and either glucose or sucrose of equal osmolality was compared in a double-blind sequential trial of 784 children with rotavirus-associated diarrhea treated at a center in rural Bangladesh. The oral fluid failure rate was 11.5% for the sucrose-containing group (P = NS). Vomiting was a significantly more common cause of failure for the group treated with sucrose-containing oral rehydration solution and was associated with an increased rate of intake of the sweeter sucrose-containing solution. The purging rate was not different for the two groups. The oral fluid failure rates for children in the most underweight category (<60% of expected weight for age) were not different from those for other groups, although as assessed by purging rate and initial dehydration, the stool losses of members of this group constituted a greater proportion of their body weight. Glucose is the preferred carbohydrate for oral electrolyte solutions, although sucrose can be substituted with only minimum loss of efficacy.

Original languageEnglish (US)
Pages (from-to)79-83
Number of pages5
JournalPediatrics
Volume67
Issue number1
StatePublished - Mar 16 1981
Externally publishedYes

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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