Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes

Bouchra Taïb; Khalil Bouyakdan; Cécile Hryhorczuk; Demetra Rodaros; Stephanie Fulton; Thierry Alquier

doi:10.1074/jbc.M113.506238

Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes

Bouchra Taïb, Khalil Bouyakdan, Cécile Hryhorczuk, Demetra Rodaros, Stephanie Fulton, Thierry Alquier

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Background: Hypothalamic long-chain fatty acids (LCFA) and glucose are critical for energy balance, but it is not known if their metabolism is coupled. Results: Glucose regulates hypothalamic metabolism of palmitate via AMP-activated kinase. Conclusion: Glucose and LCFA metabolism is coupled in a cell-type and LCFA-dependent manner. Significance: This is the first evidence for glucose regulation of LCFA metabolic fate in the hypothalamus.

Original language	English (US)
Pages (from-to)	37216-37229
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	52
DOIs	https://doi.org/10.1074/jbc.M113.506238
State	Published - Dec 27 2013
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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title = "Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes",

abstract = "Background: Hypothalamic long-chain fatty acids (LCFA) and glucose are critical for energy balance, but it is not known if their metabolism is coupled. Results: Glucose regulates hypothalamic metabolism of palmitate via AMP-activated kinase. Conclusion: Glucose and LCFA metabolism is coupled in a cell-type and LCFA-dependent manner. Significance: This is the first evidence for glucose regulation of LCFA metabolic fate in the hypothalamus.",

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AU - Taïb, Bouchra

AU - Bouyakdan, Khalil

AU - Hryhorczuk, Cécile

AU - Rodaros, Demetra

AU - Fulton, Stephanie

AU - Alquier, Thierry

PY - 2013/12/27

Y1 - 2013/12/27

N2 - Background: Hypothalamic long-chain fatty acids (LCFA) and glucose are critical for energy balance, but it is not known if their metabolism is coupled. Results: Glucose regulates hypothalamic metabolism of palmitate via AMP-activated kinase. Conclusion: Glucose and LCFA metabolism is coupled in a cell-type and LCFA-dependent manner. Significance: This is the first evidence for glucose regulation of LCFA metabolic fate in the hypothalamus.

AB - Background: Hypothalamic long-chain fatty acids (LCFA) and glucose are critical for energy balance, but it is not known if their metabolism is coupled. Results: Glucose regulates hypothalamic metabolism of palmitate via AMP-activated kinase. Conclusion: Glucose and LCFA metabolism is coupled in a cell-type and LCFA-dependent manner. Significance: This is the first evidence for glucose regulation of LCFA metabolic fate in the hypothalamus.

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Glucose regulates hypothalamic long-chain fatty acid metabolism via AMP-activated kinase (AMPK) in neurons and astrocytes

Abstract

ASJC Scopus subject areas

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