Glucose phosphorylation rate in rat parietal cortex during normoglycemia, hypoglycemia, acute hyperglycemia, and in diabetes‐prone rats

H. E. Brøndsted, A. Gjedde

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebral metabolic rate for glucose (CMRglc) was studied in rats using [6‐‐14C]glucose. After intravenous injection, the radioactivity of the parietal cortex was corrected for loss of labeled CO2 and divided by the integral of the arterial plasma glucose concentration, determined during tracer circulation. Treatment with insulin, resulting in plasma glucose concentrations less than 2.6 mmol/l, reduced CMRglc to 64% of the values found in control animals. CMRglc did not change in animals with acute hyperglycemia produced by intraperitoneal injection of a glucose solution or in diabetes‐prone rats with or without insulin treatment.

Original languageEnglish (US)
Pages (from-to)233-236
Number of pages4
JournalActa Neurologica Scandinavica
Volume81
Issue number3
DOIs
StatePublished - Mar 1990

Keywords

  • brain metabolism
  • diabetes‐prone
  • glucose phosphorylation
  • hyperglycemia
  • hypoglycemia
  • rat brain

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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