Glucose Metabolism in Cancer: The Warburg Effect and Beyond

Sminu Bose, Cissy Zhang, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate even in the presence of oxygen. The significance of this finding, later termed the Warburg effect, went unnoticed by the broader scientific community at that time. The field of cancer metabolism lay dormant for almost a century awaiting advances in molecular biology and genetics, which would later open the doors to new cancer therapies [2, 3].

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages3-15
Number of pages13
DOIs
StatePublished - 2021

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1311
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cancer metabolism
  • Gluconeogenesis
  • Glucose metabolism
  • Glycogenolysis
  • Warburg effect

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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