Glucose metabolism in cancer

Sminu Bose, Anne Le

Research output: Chapter in Book/Report/Conference proceedingChapter

35 Scopus citations

Abstract

Tumor cells exhibit an upregulation in glycolysis, glycogen metabolism, and gluconeogenesis as opposed to normal cells.The metabolic reprogramming underlying the Warburg effect and other changes in glucose metabolism are driven by several oncogenes and tumor suppressors.Numerous therapies based on cancer metabolism have been developed but have yet to show success in clinical trials.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages3-12
Number of pages10
DOIs
StatePublished - 2018
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1063
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Cancer metabolism
  • Gluconeogenesis
  • Glucose metabolism
  • Glycogenolysis
  • Warburg effect

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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